Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid

dc.creatorSilva, G. P.
dc.creatorCruz, S. C.
dc.creatorCruz, A. C.
dc.creatorMilagres, L. G.
dc.date2019-10-04T11:50:28Z
dc.date2019-10-04T11:50:28Z
dc.date2013
dc.date.accessioned2023-09-26T22:33:09Z
dc.date.available2023-09-26T22:33:09Z
dc.identifierSILVA, G. P. et al. Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid. Brazilian Journal of Medical and Biological Research, v. 46, p. 148-153, 2013.
dc.identifier0100-879X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36159
dc.identifier10.1590/1414-431X20122556
dc.identifier1414-431X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880568
dc.descriptionSimone da Costa Cruz Silva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
dc.descriptionSerogroup B Neisseria meningitidis (MenB) is a major cause of invasive disease in early childhood worldwide. The only MenB vaccine available in Brazil was produced in Cuba and has shown unsatisfactory efficacy when used to immunize millions of children in Brazil. In the present study, we compared the specific functional antibody responses evoked by the Cuban MenB vaccine with a standard vaccine against diphtheria (DTP: diphtheria, tetanus, pertussis) after primary immunization and boosting of mice. The peak of bactericidal and opsonic antibody titers to MenB and of neutralizing antibodies to diphtheria toxoid (DT) was reached after triple immunization with the MenB vaccine or DTP vaccine, respectively. However, 4 months after immunization, protective DT antibody levels were present in all DTP-vaccinated mice but in only 20% of the mice immunized against MenB. After 6 months of primary immunization, about 70% of animals still had protective neutralizing DT antibodies, but none had significant bactericidal antibodies to MenB. The booster doses of DTP or MenB vaccines produced a significant antibody recall response, suggesting that both vaccines were able to generate and maintain memory B cells during the period studied (6 months post-triple immunization). Therefore, due to the short duration of serological memory induced by the MenB vaccine (VA-MENGOC-BCH vaccine), its use should be restricted to outbreaks of meningococcal disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.rightsopen access
dc.subjectSerological memory
dc.subjectAntibody recall response
dc.subjectBooster immunization
dc.titleShort-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
dc.typeArticle


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