Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas

dc.creatorGomes, Larissa Rodrigues
dc.creatorOliveira, Natália Ketrin Almeida de
dc.creatorLavigne, Aline Rosa de
dc.creatorLima, Suelen Rezende Félix de
dc.creatorCosta, Anielle de Pina
dc.creatorBrasil, Patrícia
dc.creatorDaniel-Ribeiro, Cláudio Tadeu
dc.creatorMénard, Didier
dc.creatorCruz, Maria de Fátima Ferreira da
dc.date2016-12-27T12:44:02Z
dc.date2016-12-27T12:44:02Z
dc.date2016
dc.date.accessioned2023-09-26T22:32:56Z
dc.date.available2023-09-26T22:32:56Z
dc.identifierGOMES, Larissa Rodrigues; et al. Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non‑endemic Brazilian areas. Malaria Journal, v.15, n.96, 5p, 2016.
dc.identifier1475-2875
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16573
dc.identifier10.1186/s12936-016-1141-9
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880562
dc.descriptionPlasmodium vivax is the most widely distributed species causing the highest number of malaria cases in the world. In Brazil, P. vivax is responsible for approximately 84 % of reported cases. In the absence of a vaccine, control strategies are based on the management of cases through rapid diagnosis and adequate treatment, in addition to vector control measures. The approaches used to investigate P. vivax resistance to chloroquine (CQ) were exclusively in vivo studies because of the difficulty in keeping parasites in continuous in vitro culture. In view of the limitations related to follow-up of patients and to assessing the plasma dosage of CQ and its metabolites, an alternative approach to monitor chemo-resistance (QR) is to use molecular markers. Single nucleotide polymorphisms (SNPs) in the multidrug resistance gene pvmdr1 are putative determinants of CQ resistance (CQR), but such SNPs in P. vivax isolates from patients with good response to treatment should be further explored. The aim of this study is to investigate the mutations in the gene, supposedly associated to QR, in P. vivax isolates from successfully cured patients, living in Brazilian endemic and non-endemic areas.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectPlasmodium vivax
dc.subjectResistência à cloroquina
dc.subjectBrasil
dc.subjectPlasmodium vivax
dc.subjectChloroquine resistance
dc.subjectpvmdr1 gene
dc.subjectBrazil
dc.titlePlasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
dc.typeArticle


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