Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

dc.creatorGomes, Ana Thereza
dc.creatorCunha, Liliane Monteiro
dc.creatorBastos, Carla Guimarães
dc.creatorMedrado, Bruno Frederico
dc.creatorAssis, Bárbara Cristina Alves de
dc.creatorAndrade, Zilton de Araújo
dc.date2012-12-10T17:51:06Z
dc.date2012-12-10T17:51:06Z
dc.date2006
dc.date.accessioned2023-09-26T22:32:27Z
dc.date.available2023-09-26T22:32:27Z
dc.identifierGOMES, A. T. et al. Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses. Memórias do Instituto Oswaldo Cruz, v. 101, n. 8, p. 895-898, dec. 2006.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5948
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880517
dc.descriptionCapillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCapillaria hepatica
dc.subjectSeptal fibrosis
dc.subjectRats
dc.subjectCorticosteroids
dc.subjectAntigenic stimulation
dc.subjectCirrose Hepática Experimental/parasitologia
dc.subjectInfecções por Enoplida/parasitologia
dc.subjectCapillaria/imunologia
dc.subjectAnticorpos Anti-Helmínticos/sangue
dc.subjectAntígenos de Helmintos/administração & dosagem
dc.subjectCirrose Hepática Experimental/quimioterapia
dc.subjectCirrose Hepática Experimental/imunologia
dc.subjectInfecções por Enoplida/quimioterapia
dc.subjectInfecções por Enoplida/imunologia
dc.subjectÍndice de Gravidade de Doença
dc.subjectModelos Animais de Doenças
dc.subjectHidroxiprolina/análise
dc.subjectGlucocorticóides/uso terapêutico
dc.subjectPrednisona/uso terapêutico
dc.subjectDoença Crônica
dc.subjectRatos Wistar
dc.subjectAnimais
dc.subjectMasculino
dc.subjectFeminino
dc.subjectRatos
dc.titleCapillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
dc.typeArticle


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