The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the Spike protein (preprint)

dc.creatorResende, Paola Cristina
dc.creatorNaveca, Felipe G.
dc.creatorLins, Roberto D.
dc.creatorDezordi, Filipe Zimmer
dc.creatorFerraz, Matheus V. F.
dc.creatorMoreira, Emerson G.
dc.creatorCoêlho, Danilo F.
dc.creatorMotta, Fernando Couto
dc.creatorPaixão, Anna Carolina Dias
dc.creatorAppolinario, Luciana
dc.creatorLopes, Renata Serrano
dc.creatorMendonça, Ana Carolina da Fonseca
dc.creatorRocha, Alice Sampaio Barreto da
dc.creatorNascimento, Valdinete
dc.creatorSouza, Victor
dc.creatorSilva, George
dc.creatorNascimento, Fernanda
dc.creatorLima Neto, Lidio Gonçalves
dc.creatorRiediger, Irina
dc.creatorDebur, Maria do Carmo
dc.creatorLeite, Anderson Brandao
dc.creatorMattos, Tirza
dc.creatorCosta, Cristiano Fernandes da
dc.creatorPereira, Felicidade Mota
dc.creatorCunha, Antonio Ricardo Khouri
dc.creatorBernardes, André Felipe Leal
dc.creatorDelatorre, Edson
dc.creatorGräf, Tiago
dc.creatorSiqueira, Marilda Agudo Mendonça Teixeira de
dc.creatorBello, Gonzalo
dc.creatorWallau, Gabriel L.
dc.creatorOn behalf of Fiocruz COVID-19 Genomic Surveillance Network.
dc.date2021-09-22T18:08:06Z
dc.date2021-09-22T18:08:06Z
dc.date2021
dc.date.accessioned2023-09-26T22:30:57Z
dc.date.available2023-09-26T22:30:57Z
dc.identifierRESENDE, Paola Cristina et al. The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the Spike protein. Virus Evolution, p. 1-16, 2021.
dc.identifier2057-1577
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49135
dc.identifier10.1101/2021.03.19.21253946
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880212
dc.descriptionA Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/
dc.descriptionFiocruz COVID-19 Genomic Surveillance Network (http://www.genomahcov.fiocruz.br/) members, the Respiratory Viruses Genomic Surveillance Network of the General Laboratory Coordination (CGLab), Brazilian Ministry of Health (MoH), Brazilian Central Laboratory States (LACENs) and the Amazonas surveillance teams for the partnership in the viral surveillance in Brazil. Financial support was provided by FAPEAM (PCTI-EmergeSaude/AM call 005/2020 and Rede Genômica de Vigilancia em Saúde - REGESAM); Ministério da Ciência, Tecnologia, Inovações e Comunicações/Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq/Ministério da Saúde - MS/FNDCT/SCTIE/Decit (grants 402457/2020-9 and 403276/2020-9); Inova Fiocruz/Fundação Oswaldo Cruz (Grants VPPCB-007-FIO-18-2-30 and VPPCB-005-FIO-20-2-87) and INCT-FCx (465259/2014-6). Computer allocation was partly granted by the Brazilian National Scientific Computing Center (LNCC). FGN, GLW, RDL and GB are supported by the CNPq through their productivity research fellowships (306146/2017-7, 303902/2019-1, 425997/2018-9 and 302317/2017-1 respectively). G.B. is also funded by the Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro – FAPERJ (Grant number E-26/202.896/2018).
dc.descriptionMutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. Importantly, we detected the community transmission of different P.1 lineages bearing NTD indels Δ69-70 (which can impact several SARS-CoV-2 diagnostic protocols), Δ144 and ins214ANRN, and a new VOI N.10 derived from the B.1.1.33 lineage carrying three NTD deletions (Δ141– 144, Δ211, and Δ256–258). These findings support that the ongoing widespread transmission of SARS-CoV-2 in Brazil generates new viral lineages that might be more resistant to antibody neutralization than parental variants of concern.
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.relationhttps://www.arca.fiocruz.br/handle/icict/51756
dc.rightsopen access
dc.subjectSARS-CoV-2
dc.subjectEpítopos
dc.subjectInfecção
dc.subjectBrasil
dc.subjectMutação
dc.subjectRede Genômica Fiocruz
dc.subjectGENOMAHCOV
dc.subjectSARS-CoV-2
dc.subjectEpitopes
dc.subjectInfection
dc.subjectBrazil
dc.subjectMutation
dc.titleThe ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the Spike protein (preprint)
dc.typePreprint


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