Results of prostate cancer screening in non-symptomatic men

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAntonopoulos, I. M.
dc.creatorPompeo, A. C. L.
dc.creatorEl Hayek, O. R.
dc.creatorSarkis, A. S.
dc.creatorAlfer, W.
dc.creatorArap, S.
dc.date2014-05-27T11:20:14Z
dc.date2016-10-25T18:16:54Z
dc.date2014-05-27T11:20:14Z
dc.date2016-10-25T18:16:54Z
dc.date2001-01-01
dc.date.accessioned2017-04-06T00:59:01Z
dc.date.available2017-04-06T00:59:01Z
dc.identifierBrazilian Journal of Urology, v. 27, n. 3, p. 227-234, 2001.
dc.identifier1517-6878
dc.identifierhttp://hdl.handle.net/11449/66443
dc.identifierhttp://acervodigital.unesp.br/handle/11449/66443
dc.identifier2-s2.0-0034939110.pdf
dc.identifier2-s2.0-0034939110
dc.identifierhttp://www.brazjurol.com.br/maio_2001/Antonopoulos_227_234.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888014
dc.descriptionObjectives: To verify prostate cancer prevalence in non-symptomatic men between 50 and 70 years old as well as cancer characteristics. Material and Methods: 2815 non-symptomatic men had total PSA and digital rectal examination performed between March 1998 and April 1998. Racial distribution was: 2331 Caucasians (83.9%), 373 Blacks (13.4%) and 75 Asiatic (2.7%). PSA was normal in 2554 (91.4%), 4 to 10 in 177 (6.3%) and greater than 10 in 64 (2.3%). DRE was normal in 2419 (86.3%), suspicious in 347 (12.4%) and characteristic for cancer in 37 (1.3%). Men with abnormal DRE and/or PSA had transrectal prostate biopsy indicated. Results: 461 biopsies were done and 78 tumors was detected (prevalence = 2.8%). Prevalence was progressively higher with age (p < 0.001), PSA level (p < 0.0001) and DRE findings (p = 0.0216). Cancer prevalence in Blacks was 1.65 times higher than in Caucasians (p > 0.05) and 94.9% of detected tumors were moderately or poorly differentiated. Sensibility, specificity, positive predictive value, negative predictive value and total accuracy for PSA were respectively: 66.6%; 89.7%; 51.7%; 94.2% and 86.5%. For DRE, the respective values were: 49.1%; 79.4%; 50.9%; 78.3% and 70.3%. Conclusions: prostate cancer prevalence in the studied population (2.8%) was similar to that of other countries populations. Cancer prevalence in blacks was 1.65 times higher than in Caucasians (difference was not statistically significant). Cancer prevalence becomes higher with aging. The association of DRE and PSA is of paramount importance for cancer diagnosis. The great majority of detected tumors (94.9%) was moderately and poorly differentiated. Brazil probably needs regional studies to better characterize prostate cancer epidemiology due to population heterogeneity.
dc.languageeng
dc.relationBrazilian Journal of Urology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectProstate
dc.subjectProstate-specific antigen
dc.subjectProstatic neoplasm
dc.subjectScreening
dc.subjectprostate specific antigen
dc.subjectaccuracy
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectaging
dc.subjectAsian
dc.subjectBrazil
dc.subjectcancer diagnosis
dc.subjectcancer epidemiology
dc.subjectcancer screening
dc.subjectCaucasian
dc.subjectcontrolled study
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnegro
dc.subjectpalpation
dc.subjectpopulation
dc.subjectprediction
dc.subjectprevalence
dc.subjectprostate biopsy
dc.subjectprostate cancer
dc.subjectrace difference
dc.subjectsensitivity and sensibility
dc.subjectsensitivity and specificity
dc.subjectsymptomatology
dc.subjecttumor differentiation
dc.titleResults of prostate cancer screening in non-symptomatic men
dc.typeOtro


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