Subcutaneous and testicular metastasis from prostatic adenocarcinoma with neuroendocrine differentiation

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDénes, F. T.
dc.creatorBrito, A. H.
dc.creatorDos Santos, A. M.
dc.date2014-05-27T11:20:14Z
dc.date2016-10-25T18:16:54Z
dc.date2014-05-27T11:20:14Z
dc.date2016-10-25T18:16:54Z
dc.date2001-01-01
dc.date.accessioned2017-04-06T00:59:00Z
dc.date.available2017-04-06T00:59:00Z
dc.identifierBrazilian Journal of Urology, v. 27, n. 1, p. 52-54, 2001.
dc.identifier1517-6878
dc.identifierhttp://hdl.handle.net/11449/66440
dc.identifierhttp://acervodigital.unesp.br/handle/11449/66440
dc.identifier2-s2.0-0035067860.pdf
dc.identifier2-s2.0-0035067860
dc.identifierhttp://www.brazjurol.com.br/janeiro_2001/Denes_52_54.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888011
dc.descriptionThe pathological finding of testicular metastasis in cases of disseminated prostatic adenocarcinoma is rare, but was more frequently reported in the past, when bilateral castration was performed more often. The existence of skin and subcutaneous metastasis adds a worse prognosis, because generally it is sign of advanced disease with an average survival time of less than one year. The synchronous occurrence of such metastasis has not been described previously, neither their association to neuroendocrine differentiation. The presence of such differentiation of prostatic adenocarcinoma represents a very unfavorable prognostic factor, as suggested in recent literature. Herein, we discuss the case of a 53 year old man, who presented with macroscopic hematuria and frequency associated to several painless subcutaneous nodules in left axilla and shoulder, as well as in the lower abdominal wall. The right testis was painful, endured and on rectal examination, the prostate was diffusely enlarged. Serum PSA was elevated, reaching 1760 ng/ml and prostatic biopsy disclosed a Gleason 10 prostatic adenocarcinoma with neuroendocrine differentiation. The same pathological pattern was detected in the right testis and in all subcutaneous nodules, documented by positive staining of chromogranin, a marker of neuroendocrine cells. He was submitted to a prostate tunnelization and maximal androgen blockade plus adjuvant chemotherapy, nevertheless, he died 5 months latter.
dc.languageeng
dc.relationBrazilian Journal of Urology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeoplasm metastasis
dc.subjectNeuroendocrine differentiation
dc.subjectProstate
dc.subjectProstatic neoplasms
dc.subjectSubcutaneous
dc.subjectTestis
dc.subjectantineoplastic agent
dc.subjectcell marker
dc.subjectchromogranin
dc.subjectcyproterone
dc.subjectprostate specific antigen
dc.subjectabdominal wall
dc.subjectadjuvant chemotherapy
dc.subjectadult
dc.subjectantigen detection
dc.subjectaxilla
dc.subjectbladder wall
dc.subjectblood level
dc.subjectbone scintiscanning
dc.subjectcancer infiltration
dc.subjectcase report
dc.subjectcomputer assisted tomography
dc.subjecthematuria
dc.subjecthuman
dc.subjectmale
dc.subjectmetastasis
dc.subjectneuroendocrine tumor
dc.subjectneurosecretory cell
dc.subjectorchiectomy
dc.subjectpain
dc.subjectprostate adenocarcinoma
dc.subjectprostate biopsy
dc.subjectprostate hypertrophy
dc.subjectshoulder
dc.subjectspine metastasis
dc.subjectsubcutaneous nodule
dc.subjectsymptomatology
dc.subjecttestis
dc.subjecttumor differentiation
dc.subjecturethra
dc.titleSubcutaneous and testicular metastasis from prostatic adenocarcinoma with neuroendocrine differentiation
dc.typeOtro


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