Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection

dc.creatorDuque, Thabata L. A.
dc.creatorCascabulho, Cynthia M.
dc.creatorOliveira, Gabriel M.
dc.creatorHenriques-Pons, Andrea
dc.creatorMenna-Barreto, Rubem F. S.
dc.date2020-05-24T13:58:09Z
dc.date2020-05-24T13:58:09Z
dc.date2019
dc.date.accessioned2023-09-26T22:30:17Z
dc.date.available2023-09-26T22:30:17Z
dc.identifierDUQUE, Thabata L. A. et al. Rapamycin treatment reduces acute Moyocarditis induced by Trypanosoma cruz infection. Journal of Innate Immunity, p. 1-12, Dec. 2019.
dc.identifier1662-811x
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/41368
dc.identifier10.1159/000504322
dc.identifier1662-8128
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880079
dc.descriptionChagas disease affects millions of people mainly in Latin America and is a protozoan illness caused by the parasite Trypanosoma cruzi. Chagasic cardiomyopathy is the leading cause of mortality of infected patients, due to compromised electrical and mechanical cardiac function induced by tissue remodeling, especially fibrosis, and lymphocytic infiltration. Some cellular biochemical pathways can be protective to the heart, and we tested if the in vivo activation of the autophagic machinery by rapamycin could reduce parasite-induced myocarditis. Regarding the expression of LC3, an autophagy marker, we observed its upregulation in the cardiac tissue of infected untreated mice. However, after rapamycin treatment, an autophagy inducer, infected mice showed reduced electrical cardiac dysfunctions, myocarditis, cardiac damage, and reduced production of pro-inflammatory cytokines by the heart. On the other hand, the parasite's life cycle was not affected, and we observed no modulations in cardiac tissue or blood parasitemia. Our data indicate that, at least partially, autophagy induction controls inflammation in the heart¸ illustrating the complexity of the pathways that concur to the development of the infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherKarger
dc.rightsopen access
dc.subjectTrypanosma cruzi
dc.subjectDoença de Chagas
dc.subjectAutofagia
dc.subjectRapamycin
dc.subjectInfecção aguda
dc.subjectTrypanosoma cruzi
dc.subjectChagas Disease
dc.subjectAutophagy
dc.subjectRapamycin
dc.subjectAcute infection
dc.titleRapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
dc.typeArticle


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