Age-Standardized mortality rates related to cirrhosis in Brazil from 2000 to 2012: a nationwide analysis

dc.creatorPerazzo, Hugo
dc.creatorPacheco, Antonio G.
dc.creatorDe Boni, Raquel Brandini
dc.creatorLuz, Paula M.
dc.creatorFittipaldi, Juliana
dc.creatorCardoso, Sandra W.
dc.creatorGrinsztejn, Beatriz
dc.creatorVeloso, Valdiléa G.
dc.date2018-10-26T14:20:12Z
dc.date2018-10-26T14:20:12Z
dc.date2017
dc.date.accessioned2023-09-26T22:28:57Z
dc.date.available2023-09-26T22:28:57Z
dc.identifierPERAZZO, Hugo et al. Age-standardized mortality rates related to cirrhosis in Brazil from 2000 to 2012: a nationwide analysis. Annals of Hepatology, v. 16, n. 2, p. 269-278, 2017.
dc.identifier1665-2681
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29747
dc.identifier10.5604/16652681.1231586
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8879790
dc.descriptionBackground: Cirrhosis remains the most frequent liver-related cause of death worldwide and we aimed to evaluate its burden in Brazil from 2000 to 2012. Material and methods: The Brazilian National Death Registry was analyzed from 2000 to 2012. Death by cirrhosis was defined by the presence of I85, K73 and/or K74 ICD 10 codes in contributing or underlying causes of death on the death certificate (DC). Crude mortality rates were calculated as the ratio of the absolute number of deaths and the estimated population. Mortality rates were age-adjusted by the direct standardization method using the WHO standard population. Results: A total of 265,180 deaths where cirrhosis was mentioned on the DC [77% male, aged 56 years] occurred from 2000 to 2012. Cirrhosis codes were present in 46% of liver-related deaths and 2% of all deaths in this period. Despite an increase in the absolute number of deaths (n = 18,245 to 22,340), the age-standardized mortality rates (95%CI) decreased from 13.32 (13.16-13.48) to 11.71 (11.59-11.83) per 100,000 inhabitants from 2000 to 2012 (p < 0.001). This trend was not uniform across the country, with decreases in death rates in the South [14.46 (14.07-14.87) to 10.89 (10.59-11.19)] and Southeast [15.85 (15.6-16.09) to 12.52 (12.34-12.70)] and increases in the North [8.84 (8.24-9.43) to 11.53 (11.08-11.99)] and Northeast [9.41 (9.13-9.69) to 10.93 (10.68-11.17)] (p < 0.001 for all). Conclusion: Cirrhosis remains a major public health issue, despite the reduction in mortality rates in the last decade.
dc.description2022-12-31
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectAge-standardized mortality
dc.subjectBrazil
dc.subjectDeath certificate
dc.subjectFibrosis
dc.subjectLiver disease
dc.titleAge-Standardized mortality rates related to cirrhosis in Brazil from 2000 to 2012: a nationwide analysis
dc.typeArticle


Este ítem pertenece a la siguiente institución