Hepatitis A virus: Host interactions, molecular epidemiology and evolution

dc.creatorVaughan, Gilberto
dc.creatorRossi, Livia Maria Gonçalves
dc.creatorForbi, Joseph C.
dc.creatorPaula, Vanessa S. de
dc.creatorPurdy, Michael A.
dc.creatorXia, Guoliang
dc.creatorKhudyakov, Yury E.
dc.date2016-01-12T10:47:37Z
dc.date2016-01-12T10:47:37Z
dc.date2014
dc.date.accessioned2023-09-26T22:28:27Z
dc.date.available2023-09-26T22:28:27Z
dc.identifierVAUGHAN, Gilberto; et al. Hepatitis A virus: Host interactions, molecular epidemiology and evolution. Infection, Genetics and Evolution, v.21, p.227–243, Jan. 2014.
dc.identifier1567-1348
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12513
dc.identifier10.1016/j.meegid.2013.10.023
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8879695
dc.descriptionInfection with hepatitis A virus (HAV) is the commonest viral cause of liver disease and presents an important public health problem worldwide. Several unique HAV properties and molecular mechanisms of its interaction with host were recently discovered and should aid in clarifying the pathogenesis of hepatitis A. Genetic characterization of HAV strains have resulted in the identification of different genotypes and subtypes, which exhibit a characteristic worldwide distribution. Shifts in HAV endemicity occurring in different parts of the world, introduction of genetically diverse strains from geographically distant regions, genotype displacement observed in some countries and population expansion detected in the last decades of the 20th century using phylogenetic analysis are important factors contributing to the complex dynamics of HAV infections worldwide. Strong selection pressures, some of which, like usage of deoptimized codons, are unique to HAV, limit genetic variability of the virus. Analysis of subgenomic regions has been proven useful for outbreak investigations. However, sharing short sequences among epidemiologically unrelated strains indicates that specific identification of HAV strains for molecular surveillance can be achieved only using whole-genome sequences. Here, we present up-to-date information on the HAV molecular epidemiology and evolution, and highlight the most relevant features of the HAV-host interactions.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectHepatitis A virus
dc.subjectMolecular epidemiology
dc.subjectGenetic relatedness
dc.subjectGenotype
dc.subjectMolecular evolution
dc.subjectHost factors
dc.subjectVírus da Hepatite A
dc.subjectEpidemiologia Molecular
dc.subjectGenótipo
dc.subjectEvolução Molecular
dc.titleHepatitis A virus: Host interactions, molecular epidemiology and evolution
dc.typeArticle


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