In vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham

dc.creatorMedeiros, Maria das Graças Freire de
dc.creatorSilva, Aline Caroline da
dc.creatorCitó, Antonia Maria das Graças Lopes
dc.creatorBorges, Andrezza Raposo
dc.creatorLima, Sidney Gonçalo de
dc.creatorLopes, José Arimatéia Dantas
dc.creatorFigueiredo, Regina Celia Bressan Queiroz
dc.date2018-09-14T11:56:40Z
dc.date2018-09-14T11:56:40Z
dc.date2011
dc.date.accessioned2023-09-26T22:28:21Z
dc.date.available2023-09-26T22:28:21Z
dc.identifierMEDEIROS, M. das G. F. de et al. In vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham. Parasitology International, v. 60, n. 3, p. 237–241, set. 2011.
dc.identifier1873-0329
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28779
dc.identifier10.1016/j.parint.2011.03.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8879672
dc.descriptionCNPq , CAPES , UFPI , RENORBIO , FACEPE e FIOCRUZ
dc.descriptionLeishmaniasis is a widespread tropical infection caused by different species of Leishmania protozoa. There is no vaccine available for Leishmania infections and conventional treatments are very toxic to the patients. Therefore, antileishmanial drugs are urgently needed. In this study we have analyzed the effects of essential oils from Lippia sidoides (LSEO) and its major compound thymol on the growth, viability and ultrastructure of Leishmania amazonensis. The essential oil and thymol showed significant activity against promastigote forms of L. amazonensis, with IC(50)/48 h of 44.38 and 19.47 μg/mL respectively. However, thymol showed toxicity against peritoneal macrophages and low selectivity against the promastigotes when compared with the crude LSEO. On the other hand, no cytotoxic effect was observed in macrophages treated with the crude essential oil. Incubation of L. amazonensis-infected macrophages with LSEO showed a marked reduction in amastigote survival within the macrophages. Significant morphological alterations as accumulation of large lipid droplets in the cytoplasm, disrupted membrane and wrinkled cells were usually seen in treated parasites. The LSEO's activity against both promastigote and the amstigote forms of L. amazonensis, together with its low toxicity to mammalian cells, point to LSEO as a promising agent for the treatment of cutaneous leishmaniasis.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectLippia sidoides
dc.subjectÓleo essencial
dc.subjectAtividade antileishmanial Leishmania amazonensis
dc.subjectUltraestrutura
dc.subjectLippia sidoides
dc.subjectEssential oil
dc.subjectAntileishmanial activity Leishmania amazonensis
dc.subjectUltrastructure
dc.subjectAgentes Antiprotozoários / isolamento & purificação
dc.subjectAgentes Antiprotozoários / Farmacologia
dc.subjectConcentração Inibidora 50
dc.subjectLeishmania / efeitos de drogas
dc.subjectLeishmania / ultraestrutura
dc.subjectLeishmaniose / quimioterapia
dc.subjectLippia / química
dc.subjectMacrófagos Peritoneais / efeitos de drogas
dc.subjectÓleos Voláteis / Farmacêuticos
dc.subjectTestes de Sensibilidade Parasitária
dc.subjectExtratos Vegetais / Farmacologia
dc.subjectTimol / isolamento e purificação
dc.subjectRatos, endogâmicos BALB C
dc.subjectÓleos voláteis / química
dc.titleIn vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham
dc.typeArticle


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