Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes

dc.creatorRodrigues, Janneth
dc.creatorBrayner, Fábio André
dc.creatorAlves, Luiz Carlos
dc.creatorDixit, Rajnikant
dc.creatorBarillas-Mury, Carolina
dc.date2018-08-16T12:51:01Z
dc.date2018-08-16T12:51:01Z
dc.date2010
dc.date.accessioned2023-09-26T22:26:46Z
dc.date.available2023-09-26T22:26:46Z
dc.identifierRODRIGUES, J. et al. Hemocyte Differentiation Mediates Innate Immune Memory in Anopheles gambiae Mosquitoes. Science, v. 329, n. 5997, p. 1353–1355, 10 set. 2010.
dc.identifier1095-9203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28173
dc.identifier10.1126/science.1190689
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8879315
dc.descriptionPrograma de Pesquisa Intramural da Divisão de Pesquisa Intramural, NIAID, National Institutes of Health. FB e LA foram financiados pelas agências do governo brasileiro e do CNPq, respectivamente.
dc.descriptionMosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectMosquito
dc.subjectSistema Imune
dc.subjectImunidade Inata
dc.subjectAnopheles / imunologia
dc.subjectAnopheles / parasitologia
dc.subjectBactérias / imunologia
dc.subjectHemócitos / fisiologia
dc.subjectImunidade Inata
dc.subjectMemória Imunológica
dc.subjectPlasmodium berghei / imunologia
dc.subjectRatos
dc.subjectDiferenciação Celular
dc.subjectContagem de Colônias, Microbiana
dc.titleHemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes
dc.typeArticle


Este ítem pertenece a la siguiente institución