Modulation of virulence factors during Trypanosoma cruzi differentiation

dc.creatorOliveira, Camila
dc.creatorHoletz, Fabíola Barbieri
dc.creatorAlves, Lysangela Ronalte
dc.creatorÁvila, Andréa Rodrigues
dc.date2023-03-15T16:12:14Z
dc.date2023-03-15T16:12:14Z
dc.date2023
dc.date.accessioned2023-09-26T22:25:18Z
dc.date.available2023-09-26T22:25:18Z
dc.identifierOLIVEIRA, Camila et al. Modulation of virulence factors during Trypanosoma cruzi differentiation. Pathogens, v. 12, n. 32, p. 1–14, 2023.
dc.identifier2076-0817
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/57380
dc.identifierdoi.org/10.3390/ pathogens12010032
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878989
dc.descriptionChagas disease is a neglected tropical disease caused by Trypanosoma cruzi. This protozoan developed several mechanisms to infect, propagate, and survive in different hosts. The specific expression of proteins is responsible for morphological and metabolic changes in different parasite stages along the parasite life cycle. The virulence strategies at the cellular and molecular levels consist of molecules responsible for mediating resistance mechanisms to oxidative damage, cellular invasion, and immune evasion, performed mainly by surface proteins. Since parasite surface coat remodeling is crucial to invasion and infectivity, surface proteins are essential virulence elements. Understanding the factors involved in these processes improves the knowledge of parasite pathogenesis. Genome sequencing has opened the door to high-throughput technologies, allowing us to obtain a deeper understanding of gene reprogramming along the parasite life cycle and identify critical molecules for survival. This review therefore focuses on proteins regulated during differentiation into infective forms considered virulence factors and addresses the current known mechanisms acting in the modulation of gene expression, emphasizing mRNA signals, regulatory factors, and protein complexes.
dc.formatapplication/pdf
dc.languagepor
dc.publisherMDPI
dc.rightsopen access
dc.subjectProteínas de Superfície
dc.subjectInfecção por Trypanosoma cruzi
dc.subjectGene Expression Regulation
dc.subjectMembrane Proteins
dc.subjectChagas Disease
dc.subjectCell Differentiation
dc.subjectRegulación de la Expresión Génica
dc.subjectProteínas de la Membrana
dc.subjectEnfermedad de Chagas
dc.subjectDiferenciación Celular
dc.subjectRégulation de l'expression des gènes
dc.subjectProtéines membranaires
dc.subjectMaladie de Chagas
dc.subjectDifférenciation cellulaire
dc.subjectRegulação da Expressão Gênica
dc.subjectProteínas de Membrana
dc.subjectDoença de Chagas
dc.subjectDiferenciação Celular
dc.titleModulation of virulence factors during Trypanosoma cruzi differentiation
dc.typeArticle


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