Haematological and immunophenotypic evaluation of peripheral blood cells of cattle naturally infected with bovine papillomavirus

dc.creatorBassi, Paula Boeira
dc.creatorAraujo, Fernanda Fortes de
dc.creatorGarcia, Guilherme C.
dc.creatorSilva, Matheus Fernandes Costa e
dc.creatorBittar, Eustaquio Resende
dc.creatorBertonha, Candice Mara
dc.creatorMartins Filho, Olindo Assis
dc.creatorAraujo, Marcio Sobreira Silva
dc.creatorBittar, Joely Ferreira Figueiredo
dc.date2019-11-06T13:20:03Z
dc.date2019-11-06T13:20:03Z
dc.date2019
dc.date.accessioned2023-09-26T22:25:17Z
dc.date.available2023-09-26T22:25:17Z
dc.identifierBASSI, Paula Boeira et al. Haematological and immunophenotypic evaluation of peripheral blood cells of cattle naturally infected with bovine papillomavirus. Veterinary Journal, v. 244, p. 112-115, 2019.
dc.identifier1090-0233
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36888
dc.identifier10.1016/j.tvjl.2018.12.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878985
dc.descriptionPapillomaviruses are among the most widespread animal viruses, with many hosts harbouring multiple virus types. The present study aimed to evaluate the haematological and immunophenotypic profile of cattle infected with bovine papillomavirus (BPV). Blood samples were collected from 10 animals with clinical cutaneous BPV and without clinical papillomatosis (control). Haematological analysis demonstrated a significant reduction in haemoglobin and haematocrit for BPV-infected animals. The results also showed an increase of natural killer cells and a decrease of γδ+ T-cells and the CD4+/CD8+ ratio for the BPV group when compared to the control group. The infection was also found to stimulate a pro-inflammatory profile with the participation of CD8+T cells producing elevated IFN-γ and IL-17. These findings, although preliminary, provide a better understanding of the immune response of cattle infected with BPV.
dc.description2035-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectCattle
dc.subjectCytokines
dc.subjectImmune response
dc.subjectPapillomavirus
dc.titleHaematological and immunophenotypic evaluation of peripheral blood cells of cattle naturally infected with bovine papillomavirus
dc.typeArticle


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