Could the lower frequency of CD8+CD18+CD45RO+ lymphocytes be biomarkers of human VL?

dc.creatorClarêncio, Jorge
dc.creatorOliveira, Camila Indiani de
dc.creatorFavali, Cecilia Beatriz Fiuza
dc.creatorMedina, Omar
dc.creatorCaldas, Arlene de Jesus Mendes
dc.creatorCosta, Carlos Henrique Nery
dc.creatorCosta, Dorcas Lamounier
dc.creatorBrodskyn, Claudia Ida
dc.creatorBarral, Aldina Maria Prado
dc.creatorBarral Netto, Manoel
dc.date2011-04-12T21:55:34Z
dc.date2011-04-12T21:55:34Z
dc.date2008
dc.date.accessioned2023-09-26T22:25:09Z
dc.date.available2023-09-26T22:25:09Z
dc.identifierCLARÊNCIO, J. et al. Could the lower frequency of CD8+CD18+CD45RO+ lymphocytes be biomarkers of human VL? International Immunolgy, v.21, n.2, p. 137-144, 2008.
dc.identifier0953-8178
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/1890
dc.identifier10.1093/intimm/dxn131
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878956
dc.descriptionToward obtaining a more comprehensive understanding of factors governing activation and/or function during visceral leishmaniasis (VL), we have compared active disease (pre-treatment) versus post-chemotherapy immune response in VL patients by means of ex vivo staining with different cell markers. Our results show that during active disease, the frequency of T cells positive for CD25, CTLA-4 and CD45RO was significantly lower in VL patients compared with healthy controls, whereas cells staining positive for Annexin V and CD95 were significantly higher. In all cases, chemotherapy was able to restore these frequencies to normal levels. Interestingly, significant differences in the frequency of CD18 and in the frequency of CD45RO-positive cells were observed in the CD81 T cell subset. These two frequencies were also significantly higher in bone marrow when compared with peripheral blood, suggesting a possible compartmentalization of certain CD81 T cell populations during active disease. Given that CD81 T cells have been shown to play an essential role in immunity to infection with Leishmania, our data indicate that the lower frequency of CD181 and CD45RO1 lymphocytes in the bone marrow CD81 T cell subset may be considered a biomarker of acute VL.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCD 18
dc.subjectFlow cytometry
dc.subjectLeishmania
dc.subjectAntígenos CD18
dc.subjectAntígenos CD45
dc.subjectAntígenos de Protozoários
dc.subjectLinfócitos T CD8-Positivos
dc.subjectLeishmania infantum
dc.subjectLeishmaniose visceral
dc.subjectSub-Populações de Linfócitos T
dc.subjectCitometria de Fluxo
dc.titleCould the lower frequency of CD8+CD18+CD45RO+ lymphocytes be biomarkers of human VL?
dc.typeArticle


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