Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes

dc.creatorMelo, Tatiana G.
dc.creatorAdesse, Daniel
dc.creatorMeirelles, Maria de Nazareth
dc.creatorPereira, Mirian Claudia S.
dc.date2019-11-28T14:38:13Z
dc.date2019-11-28T14:38:13Z
dc.date2019
dc.date.accessioned2023-09-26T22:25:07Z
dc.date.available2023-09-26T22:25:07Z
dc.identifierMELO, Tatiana G. et al. Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-9, 2019.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/37459
dc.identifier10.1590/0074-02760180593
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878949
dc.descriptionCardiac physiology depends on coupling and electrical and mechanical coordination through the intercalated disc. Focal adhesions offer mechanical support and signal transduction events during heart contraction-relaxation processes. Talin links integrins to the actin cytoskeleton and serves as a scaffold for the recruitment of other proteins, such as paxillin in focal adhesion formation and regulation. Chagasic cardiomyopathy is caused by infection by Trypanosoma cruzi and is a debilitating condition comprising extensive fibrosis, inflammation, cardiac hypertrophy and electrical alterations that culminate in heart failure.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectCardiomiócito
dc.subjectAdesão focal
dc.subjectTalina
dc.subjectTrypanosoma cruzi
dc.subjectCardiomyocyte
dc.subjectFocal adhesion
dc.subjectTalin
dc.subjectPaxilin
dc.subjectMechanotransduction
dc.subjectMecanotransdução
dc.subjectTalina
dc.titleTrypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
dc.typeArticle


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