| dc.creator | Grimaldi Jr., Gabriel | |
| dc.date | 2017-06-06T13:59:25Z | |
| dc.date | 2017-06-06T13:59:25Z | |
| dc.date | 2008 | |
| dc.date.accessioned | 2023-09-26T22:23:54Z | |
| dc.date.available | 2023-09-26T22:23:54Z | |
| dc.identifier | GRIMALDI JR., Gabriel. The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review. Mem. Inst. Oswaldo Cruz, v.103, n.7, p.629-644. 2008. | |
| dc.identifier | 0074-0276 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/19317 | |
| dc.identifier | 10.1590/S0074-02762008000700002 | |
| dc.identifier | 1678-8060 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8878739 | |
| dc.description | Leishmaniasis causes significant morbidity and mortality, constituting an important global health problem for
which there are few effective drugs. Given the urgent need to identify a safe and effective Leishmania vaccine to help
prevent the two million new cases of human leishmaniasis worldwide each year, all reasonable efforts to achieve this
goal should be made. This includes the use of animal models that are as close to leishmanial infection in humans as
is practical and feasible. Old world monkey species (macaques, baboons, mandrills etc.) have the closest evolutionary
relatedness to humans among the approachable animal models. The Asian rhesus macaques (Macaca mulatta)
are quite susceptible to leishmanial infection, develop a human-like disease, exhibit antibodies to Leishmania and
parasite-specific T-cell mediated immune responses both in vivo and in vitro, and can be protected effectively by
vaccination. Results from macaque vaccine studies could also prove useful in guiding the design of human vaccine
trials. This review summarizes our current knowledge on this topic and proposes potential approaches that may result
in the more effective use of the macaque model to maximize its potential to help the development of an effective
vaccine for human leishmaniasis. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | |
| dc.rights | open access | |
| dc.subject | Primatas não-humanos | |
| dc.subject | Desenvolvimento da vacina Leishmania | |
| dc.subject | Leishmaniose experimental | |
| dc.subject | experimental leishmaniasis | |
| dc.subject | Leishmania vaccine development | |
| dc.subject | non-human primates | |
| dc.title | The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review | |
| dc.type | Article | |
