Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria

dc.creatorKayano, Ana Carolina A. V.
dc.creatorSantos, João Conrado K. dos
dc.creatorBastos, Marcele F.
dc.creatorCarvalho, Leonardo J.
dc.creatorAliberti, Júlio
dc.creatorCosta, Fabio T. M.
dc.date2016-12-27T11:29:02Z
dc.date2016-12-27T11:29:02Z
dc.date2016
dc.date.accessioned2023-09-26T22:23:27Z
dc.date.available2023-09-26T22:23:27Z
dc.identifierKAYANO, Ana Carolina A. V. et al. Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria. Infection and Immunity, v.84, n.4, p.874-882, Apr. 2016.
dc.identifier0019-9567
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16570
dc.identifier10.1128/IAI.01404-15
dc.identifier1098-5522
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878633
dc.descriptionOver 200 million people worldwide suffer from malaria every year, a disease that causes 584,000 deaths annually. In recent years, significant improvements have been achieved on the treatment of severe malaria, with intravenous artesunate proving superior to quinine. However, mortality remains high, at 8% in children and 15% in adults in clinical trials, and even worse in the case of cerebral malaria (18% and 30%, respectively). Moreover, some individuals who do not succumb to severe malaria present long-term cognitive deficits. These observations indicate that strategies focused only on parasite killing fail to prevent neurological complications and deaths associated with severe malaria, possibly because clinical complications are associated in part with a cerebrovascular dysfunction. Consequently, different adjunctive therapies aimed at modulating malaria pathophysiological processes are currently being tested. However, none of these therapies has shown unequivocal evidence in improving patient clinical status. Recently, key studies have shown that gaseous therapies based mainly on nitric oxide (NO), carbon monoxide (CO), and hyperbaric (pressurized) oxygen (HBO) alter vascular endothelium dysfunction and modulate the host immune response to infection. Considering gaseous administration as a promising adjunctive treatment against severe malaria cases, we review here the pathophysiological mechanisms and the immunological aspects of such therapies.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society for Microbiology
dc.rightsopen access
dc.subjectMalária
dc.subjectMecanismos Fisiopatológicos
dc.subjectTerapias gasosas
dc.subjectsevere malaria
dc.subjectPathophysiological Mechanisms
dc.subjectGaseous Therapies
dc.titlePathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
dc.typeArticle


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