Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis

dc.creatorGiunchetti, Rodolfo Cordeiro
dc.creatorMayrink, Wilson
dc.creatorCarneiro, Cláudia Martins
dc.creatorOliveira, Rodrigo Corrêa de
dc.creatorMartins Filho, Olindo Assis
dc.creatorMarques, Marcos José
dc.creatorTafuri, Washington Luiz
dc.creatorReis, Alexandre Barbosa
dc.date2022-01-28T16:42:47Z
dc.date2022-01-28T16:42:47Z
dc.date2008
dc.date.accessioned2023-09-26T22:23:26Z
dc.date.available2023-09-26T22:23:26Z
dc.identifierGIUNCHETTI, Rodolfo Cordeiro et al. Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis. Research in Veterinary Science, v. 84, n. 2, p. 269-277, 2008. doi: 10.1016/j.rvsc.2007.04.020.
dc.identifier0034-5288
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50938
dc.identifier10.1016/j.rvsc.2007.04.020
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878629
dc.descriptionCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
dc.descriptionThe immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in canine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with Leishmania chagasi [i.e., asymptomatic (AD, n = 12), oligosymptomatic (OD, n = 12) and symptomatic (SD, n = 17)] were assessed and compared with a group of non-infected dogs (NID, n = 11). Intense reaction of the Kupffer cells, capsule and portal inflammation, and the presence of intralobular granulomas, were observed in the different clinical groups. Dogs in the SD group presented a higher frequency of parasitism compared with the AD group. Inflammatory alterations were more intense in the SD group and were associated with parasitism. Our results indicated an association between histological liver changes and the progression of biochemical alterations according to progression of clinical forms of CVL, and the direct relationship between clinical symptoms and frequency of hepatic parasitism.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBritish Veterinary Association
dc.rightsrestricted access
dc.subjectdog
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectLDU index
dc.subjectLeishmania chagasi
dc.subjectliver
dc.subjectparasitism
dc.subjectvisceral leishmaniasis
dc.titleHistopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis
dc.typeArticle


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