Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil

dc.creatorArantes, Ighor
dc.creatorGräf, Tiago
dc.creatorAndrade, Paula
dc.creatorChaves, Yury Oliveira
dc.creatorGuimarães, Monick Lindenmeyer
dc.creatorBello, Gonzalo
dc.date2022-04-06T17:39:59Z
dc.date2022-04-06T17:39:59Z
dc.date2022
dc.date.accessioned2023-09-26T22:22:17Z
dc.date.available2023-09-26T22:22:17Z
dc.identifierARANTES, Ighor et al. Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil. Front. Microbiol.,
dc.identifier1664-302X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/52062
dc.identifier10.3389/fmicb.2022.835443
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878420
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Fundação Oswaldo Cruz (FIOCRUZ).
dc.descriptionThe HIV-1 epidemic in the Amazonas state, as in most of Brazil, is dominated by subtype B. The state, nonetheless, is singular for its significant co-circulation of the variants BCAR, which can mostly be found in the Caribbean region, and BPAN, a clade that emerged in the United States and aggregates almost the totality of subtype B infections world-wide. The Amazonian HIV-1 epidemic provides a unique scenario to compare the epidemic potential of BPAN and BCAR clades spreading in the same population. To reconstruct the spatiotemporal dynamic and demographic history of both subtype B lineages circulating in Amazonas, we analyzed 1,272 HIV-1 pol sequences sampled in that state between 2009 and 2018. Our phylogeographic analyses revealed that while most BCAR infections resulted from a single successful founder event that took place in the Amazonas state around the late 1970s, most BPAN infections resulted from the expansion of multiple clusters seeded in the state since the late 1980s. Our data support the existence of at least four large clusters of the pandemic form in Amazonas, two of them nested in Brazil’s largest known subtype B cluster (BBR–I), and two others resulting from new introductions detected here. The reconstruction of the demographic history of the most prevalent BPAN (n = 4) and BCAR (n = 1) clades identified in Amazonas revealed that all clades displayed a continuous expansion [effective reproductive number (Re) > 1] until most recent times. During the period of co-circulation from the late 1990s onward, the Re of Amazonian BPAN and BCAR clusters behaved quite alike, fluctuating between 2.0 and 3.0. These findings support that the BCAR and BPAN variants circulating in the Brazilian state of Amazonas displayed different evolutionary histories, but similar epidemic trajectories and transmissibility over the last two decades, which is consistent with the notion that both subtype B variants display comparable epidemic potential. Our findings also revealed that despite significant advances in the treatment of HIV infections in the Amazonas state, BCAR and BPAN variants continue to expand and show no signs of the epidemic stabilization observed in other parts of the country.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectHIV-1
dc.subjectBrasil
dc.subjectAmazona
dc.subjectEpidemias
dc.subjectHIV-1
dc.subjectBrazil
dc.subjectAmazona
dc.subjectEpidemics
dc.subjectVIH-1
dc.subjectBrasil
dc.subjectAmazona
dc.subjectEpidemias
dc.subjectVIH-1 (Virus de l'Immunodéficience Humaine de type 1)
dc.subjectBrésil
dc.subjectAmazona
dc.subjectÉpidémies
dc.titleDissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
dc.typeArticle


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