Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni.

dc.creatorOliveira, Sheilla Andrade de
dc.creatorSilva, Luciana Menezes da
dc.creatorBarbosa Junior, Aryon de Almeida
dc.creatorSantos, Ricardo Ribeiro dos
dc.creatorCoutinho, Elsimar Metzker
dc.creatorAndrade, Zilton de Araújo
dc.creatorSoares, Milena Botelho Pereira
dc.date2015-04-13T17:55:24Z
dc.date2015-04-13T17:55:24Z
dc.date2004
dc.date.accessioned2023-09-26T22:21:25Z
dc.date.available2023-09-26T22:21:25Z
dc.identifierOLIVEIRA, S. A. Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni. Parasitology Research, v. 93, n. 1, p. 30-35, 2004.
dc.identifier0932-0113
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9959
dc.identifier10.1007/s00436-004-1088-6
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878271
dc.description: We previously demonstrated that mice subjected to a hypoproteinic diet showed milder chronic lesions on infection with Schistosoma mansoni than normally fed mice. Here we compare the immune response of well-nourished and undernourished mice with chronic S. mansoni infection. The proliferative response and cytokine (IFN-gamma and IL-5) production of splenocytes from undernourished mice against the soluble egg antigen (SEA) of S. mansoni or concanavalin A was similar to that of well-nourished mice. The levels of SEA-specific IgG1, IgG2b and IgG3 antibodies were significantly higher in the sera of well-nourished mice in comparison with undernourished mice. Undernourished animals also exhibited diminished periovular granuloma size compared to well-nourished infected controls. Our results support the importance of host nutritional status in the humoral immune response of mice and its effects on the development of periovular granulomas in malnourished animals infected with S. mansoni.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag
dc.rightsopen access
dc.subjectAnticorpos Anti-Helmínticos/sangue
dc.subjectGranuloma/patologia
dc.subjectTranstornos Nutricionais/imunologia
dc.subjectSchistosoma mansoni/imunologia
dc.subjectEsquistossomose mansoni/patologia
dc.subjectFenômenos Fisiológicos da Nutrição Animal
dc.subjectAnimais
dc.subjectAntígenos de Helmintos/imunologia
dc.subjectFeminino
dc.subjectGranuloma/imunologia
dc.subjectFígado/imunologia
dc.subjectAtivação Linfocitária
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectTranstornos Nutricionais/patologia
dc.subjectEsquistossomose mansoni/imunologia
dc.subjectBaço/patologia
dc.titleDecreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni.
dc.typeArticle


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