The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies

dc.creatorYu, Bing
dc.creatorZanetti, Krista A.
dc.creatorTemprosa, Marinella
dc.creatorAlbanes, Demetrius
dc.creatorAppel, Nathan
dc.creatorBarrera, Clara Barrios
dc.creatorBen-Shlomo, Yoav
dc.creatorBoerwinkle, Eric
dc.creatorCasas, Juan P.
dc.creatorClish, Clary
dc.creatorDale, Caroline
dc.creatorDehghan, Abbas
dc.creatorDerkach, Andriy
dc.creatorEliassen, A Heather
dc.creatorElliott, Paul
dc.creatorFahy, Eoin
dc.creatorGieger, Christian
dc.creatorGunter, Marc J.
dc.creatorHarada, Sei
dc.creatorHarris, Tamara
dc.creatorHerr, Deron R.
dc.creatorHerrington, David
dc.creatorHirschhorn, Joel N
dc.creatorHoover, Elise
dc.creatorHsing, Ann W.
dc.creatorJohansson, Mattias
dc.creatorKelly, Rachel S
dc.creatorKhoo, Chin Meng
dc.creatorKivimäki, Mika
dc.creatorKristal, Bruce S.
dc.creatorLangenberg, Claudia
dc.creatorLasky-Su, Jessica
dc.creatorLawlor, Deborah A.
dc.creatorLotta, Luca A
dc.creatorMangino, Massimo
dc.creatorMarchand, Loïc Le
dc.creatorMathé, Ewy
dc.creatorMatthews, Charles E.
dc.creatorMenni, Cristina
dc.creatorMucci, Lorelei A.
dc.creatorMurphy, Rachel
dc.creatorOresic, Matej
dc.creatorOrwoll, Eric
dc.creatorOse, Jennifer
dc.creatorPereira, Alexandre C.
dc.creatorPlaydon, Mary C.
dc.creatorPoston, Lucilla
dc.creatorPrice, Jackie
dc.creatorQi, Qibin
dc.creatorRexrode, Kathryn
dc.creatorRisch, Adam
dc.creatorSampson, Joshua
dc.creatorSeow, Wei Jie
dc.creatorSesso, Howard D.
dc.creatorShah, Svati H.
dc.creatorShu, Xiao-Ou
dc.creatorSmith, Gordon C. S.
dc.creatorSovio, Ulla
dc.creatorStevens Victoria L.
dc.creatorStolzenberg-Solomon, Rachael
dc.creatorTakebayashi, Toru
dc.creatorTillin, Therese
dc.creatorTravis, Ruth
dc.creatorTzoulaki, Ioanna
dc.creatorUlrich, Cornelia M.
dc.creatorVasan, Ramachandran S.
dc.creatorVerma, Mukesh
dc.creatorWang, Ying
dc.creatorWareham, Nick J.
dc.creatorWong, Andrew
dc.creatorYounes, Naji
dc.creatorZhao, Hua
dc.creatorZheng, Wei
dc.creatorMoore, Steven C.
dc.date2019-08-21T19:20:38Z
dc.date2019-08-21T19:20:38Z
dc.date2019
dc.date.accessioned2023-09-26T22:21:14Z
dc.date.available2023-09-26T22:21:14Z
dc.identifierYU, Bin et al. The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. American Journal of Epidemiology, v. 188, n. 6, p. 991-1012, 2019.
dc.identifier0002-9262
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34950
dc.identifier10.1093/aje/kwz028
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878239
dc.descriptionAlexandre C. Pereira. Fundação Oswaldo Cruz. Instituto de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil.
dc.descriptionThe Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprised 47 cohorts from Asia, Europe, North America and South America that together include 137, 000+ participants with blood metabolomics data on samples collected from 1985-2017. Metabolomics data were provided by 17 different platforms with the most frequently used labs being Metabolon Inc. (14 cohorts), the Broad Institute (15 cohorts), and Nightingale Health (11 cohorts). Participants were followed for a median 23 years for health outcomes, including death, cancer, cardiovascular disease, diabetes and others. Available exposure-related data include common clinical measurements, behavioral factors, as well as genome-wide genotype data. Two feasibility studies were conducted to evaluate the comparability of metabolomics platforms used by COMETS cohorts. The first study showed that the overlap between any two different laboratories ranged from 6 to 121 metabolites at five leading laboratories. The second study showed that the median Spearman correlation comparing 111 overlapping metabolites captured by Metabolon and the Broad Institute was 0.79 (interquartile range: 0.56-0.89).
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsrestricted access
dc.subjectCancer
dc.subjectCohort
dc.subjectEpidemiology
dc.subjectGenetics
dc.subjectHeart disease
dc.subjectMetabolomics
dc.subjectProspective
dc.titleThe Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies
dc.typeArticle


Este ítem pertenece a la siguiente institución