A heme-degradation pathway in a blood-sucking insect

dc.creatorSilva, Gabriela O. Palva
dc.creatorOliveira, Christine Cruz
dc.creatorNakayasu, Ernesto S.
dc.creatorMaya-Monteiro, Clarissa M.
dc.creatorDunkov, Boris C.
dc.creatorMasuda, Hatisaburo
dc.creatorAlmeida, Igor C.
dc.creatorOliveira, Pedro L.
dc.date2020-01-29T15:56:42Z
dc.date2020-01-29T15:56:42Z
dc.date2006
dc.date.accessioned2023-09-26T22:20:39Z
dc.date.available2023-09-26T22:20:39Z
dc.identifierSILVA, Gabriela O. Paiva et al. A heme-degradation pathway in a blood-sucking insect. PNAS, v. 103, n. 21, p. 8030-8035, May 2006.
dc.identifier0027-8424
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39586
dc.identifier10.1073/pnas.0602224103
dc.identifier1091-6490
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8878110
dc.descriptionHematophagous insects are vectors of diseases that affect hundreds of millions of people worldwide. A common physiological event in the life of these insects is the hydrolysis of host hemoglobin in the digestive tract, leading to a massive release of heme, aknownprooxidantmolecule.Diverseorganisms,frombacteriato plants, express the enzyme heme oxygenase, which catalyzes the oxidative degradation of heme to biliverdin (BV) IX, CO, and iron. Here, we show that the kissing bug Rhodnius prolixus, a vector of Chagas’disease,hasauniqueheme-degradationpathwaywherein heme is first modified by addition of two cysteinylglycine residues beforecleavageoftheporphyrinring,followedbytrimmingofthe dipeptides. Furthermore, in contrast to most known heme oxygenases, which generate BV IX , in this insect, the end product of hemedetoxificationisadicysteinyl-BVIX .Basedontheseresults, we propose a heme metabolizing pathway that includes the identified intermediates produced during modification and cleavage of the heme porphyrin ring.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNational Academy of Sciences
dc.rightsopen access
dc.subjectRhodnius
dc.subjectEstresse oxidativo
dc.subjectBiliverdin
dc.subjectHeme oxygenase
dc.subjectBiliverdin
dc.subjectHeme oxygenase
dc.subjectOxidative stress
dc.subjectRhodnius
dc.titleA heme-degradation pathway in a blood-sucking insect
dc.typeArticle


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