Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice

dc.creatorAlmeida, Mariana Silva
dc.creatorCarvalho, Luiz O. P.
dc.creatorSilva, Ana L. Abreu
dc.creatorSouza, Celeste S. F.
dc.creatorHardoim, Daiana J.
dc.creatorCalabrese, Kátia S.
dc.date2017-04-09T17:53:02Z
dc.date2017-04-09T17:53:02Z
dc.date2012
dc.date.accessioned2023-09-26T22:18:56Z
dc.date.available2023-09-26T22:18:56Z
dc.identifierALMEIDA, Mariana Silva; et al. Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice. Veterinary Research, v.43, n.10, 9p, 2012.
dc.identifier0928-4249
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18336
dc.identifier10.1186/1297-9716-43-10
dc.identifier1297-9716
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8877727
dc.descriptionLeishmania is inoculated, by the bite of an infected sandfly, into the skin of the host, where the promastigotes are phagocyted by dermal macrophages. The dermal region comprises cells and abundant extracellular matrix. Studies show that matrix metalloproteinases play an important role in host defense responses against pathogens in mammals and that their activities lead to the production of antimicrobial peptides. The aim of this study is to evaluate the changes in the distribution of fibronectin and laminin as well as in the elastic system fibres during the course of infection caused by Leishmania amazonensis in mice with distinct genetic backgrounds of susceptibility to this parasite. The results showed that BALB/c presented an enhancement of fibronectin during the course of infection when compared to their control group while the infected or non-infected C3H.He showed a decrease of this protein at end of the experiment. Laminin, on the other hand, remained unaltered in both strains. Also in both BALB/c and C3H.He mice the elastic and elaunin fibres remained unchanged while the oxytalan fibres decreased along the experiment. Ninety days after the infection C3H.He mice had recovered their capacity to produce oxytalan fibres.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectLeishmaniose
dc.subjectLaminina 
dc.subjectFibronectinas 
dc.subjectAlterações da matriz extracelular
dc.subjectInfecção
dc.subjectLeishmania amazonensis
dc.subjectfibronectin
dc.subjectlaminin
dc.subjectoxytalan fibres
dc.subjectExtracellular matrix alterations
dc.subjectinfection
dc.titleExtracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
dc.typeArticle


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