Double-blind comparison of venlafaxine and amitriptyline in outpatients with major depression with or without melancholia

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGentil, Valentim
dc.creatorTiosso, Ana
dc.creatorBenedictis, Eliana
dc.creatorKerr-Correa, Florence
dc.creatorMoreno, Ricardo
dc.creatorD'Arrigo Busnello, Ellis
dc.creatorCampos, João Alberto de
dc.creatorJuruena, Mario Francisco
dc.creatorLafer, Beny
dc.creatorMoreno, Doris Hupfeld
dc.creatorRosa, Lucena de Cássia Rodrigues
dc.date2014-05-27T11:19:54Z
dc.date2016-10-25T18:16:20Z
dc.date2014-05-27T11:19:54Z
dc.date2016-10-25T18:16:20Z
dc.date2000-03-29
dc.date.accessioned2017-04-06T00:56:48Z
dc.date.available2017-04-06T00:56:48Z
dc.identifierJournal of Psychopharmacology, v. 14, n. 1, p. 61-66, 2000.
dc.identifier0269-8811
dc.identifierhttp://hdl.handle.net/11449/66130
dc.identifierhttp://acervodigital.unesp.br/handle/11449/66130
dc.identifier10.1177/026988110001400108
dc.identifier2-s2.0-0034021822
dc.identifierhttp://dx.doi.org/10.1177/026988110001400108
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887758
dc.descriptionThe purpose of this study was to compare the efficacy and tolerability of venlafaxine and amitriptyline in outpatients with major depression with or without melancholia. This was an 8-week, multicentre, randomized, double-blind, parallel-group comparison of venlafaxine and amitriptyline. Outpatients with DSM-IV major depression, a minimum score of 20 on the 21-item Hamilton Depression Rating Scale (HAM-D), and depressive symptoms for at least 1 month were eligible. Patients were randomly assigned to venlafaxine or amitriptyline, both drugs titrated to a maximum of 150 mg/day until study day 15. The primary efficacy variables were the final on-therapy scores on the HAM-D, Montgomery-Asberg Depression Rating Scale and Clinical Global Impression severity scales. Data were evaluated on an intent-to-treat basis using the LOCF method. One hundred and 16 patients were randomized, and 115 were evaluated for efficacy. Both drugs showed efficacy in the treatment of depression with or without melancholia. No significant differences were noted between treatments for any efficacy parameter. However, significantly (p < 0.05) more patients in the amitriptyline group had at least one adverse event. These results should support the efficacy and tolerability of venlafaxine in comparison with amitriptyline for treating major depression with or without melancholia.
dc.languageeng
dc.relationJournal of Psychopharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmitriptyline
dc.subjectDepression
dc.subjectMelancholia
dc.subjectVenlafaxine
dc.subjectamitriptyline
dc.subjectvenlafaxine
dc.subjectadult
dc.subjectappetite disorder
dc.subjectclinical trial
dc.subjectconstipation
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdata analysis
dc.subjectdepression
dc.subjectdisease severity
dc.subjectdouble blind procedure
dc.subjectdrug efficacy
dc.subjectdrug tolerability
dc.subjectfemale
dc.subjectHamilton scale
dc.subjectheadache
dc.subjecthuman
dc.subjecthypertension
dc.subjectinsomnia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmelancholia
dc.subjectmulticenter study
dc.subjectnausea
dc.subjectoutpatient care
dc.subjectparesthesia
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectrash
dc.subjectrating scale
dc.subjectsomnolence
dc.subjectsweating
dc.subjectsymptom
dc.subjecttaste disorder
dc.subjecttremor
dc.subjectvertigo
dc.subjectvisual impairment
dc.subjectxerostomia
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAmbulatory Care
dc.subjectAntidepressive Agents, Second-Generation
dc.subjectAntidepressive Agents, Tricyclic
dc.subjectCyclohexanols
dc.subjectDepressive Disorder
dc.subjectDepressive Disorder, Major
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPersonality Inventory
dc.subjectTreatment Outcome
dc.titleDouble-blind comparison of venlafaxine and amitriptyline in outpatients with major depression with or without melancholia
dc.typeOtro


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