Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?

dc.creatorRios, Fernanda Ferreira
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorCodes, Liana
dc.creatorSantos Junior, Genario Oliveira
dc.creatorSchinoni, Maria Isabel
dc.creatorParaná, Raymundo
dc.date2017-03-03T18:07:33Z
dc.date2017-03-03T18:07:33Z
dc.date2016
dc.date.accessioned2023-09-26T22:17:35Z
dc.date.available2023-09-26T22:17:35Z
dc.identifierRIOS, F. F. et al. Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence? Annals of Hepatology, v. 15, n. 6, p. 932-938, 2016.
dc.identifier1665-2681
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17926
dc.identifier10.5604/16652681.1222113
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8877423
dc.description Introduction and aim. Non-cirrhotic idiopathic portal hypertension (NCIPH), also known as hepatoportal sclerosis (HPS) is a disease of uncertain etiology. However, various pathophysiological mechanisms has been postulated, including chronic or recurrent infections and exposure to drugs or toxins. In this context, it appears to be of multifactorial etiology or resulting from a portal vascular endothelium aggression. It is important to consider whether the use of dietary supplements and herbs can trigger or contribute to the occurance of HPS. We report a possible association of HPS with the consumption of herbals and / or dietary supplements.Material and methods. We describe two cases of HPS in patients without known etiology causes associated with this disease. Results. Both patients were females who were diagnosed with HPS following the consumption of Herbalife® products and putative anorexigenic agents in the herbal infusions. Image-based analysis and the assessment of the histopathological alterations found in the livers confirmed the diagnosis. The histopatological analysis of liver samples from both patients showed portal tracts enlarged by fibrosis with disappearance or reduction in the diameter of the portal vein branches. In many portal tracts, portal veins branches were replaced by aberrant thin-walled fendiforme vessels. The bile ducts and branches of the hepatic artery show normal aspects. Conclusion. After the exclusion of other etiologic factors and a comprehensive analysis of clinical history, consumption of Herbalife® products and anorexigenic agents was pointed-out as a puttative predisposing factor for the development of the disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherDesconhecida
dc.rightsopen access
dc.subjectFibrose portal não cirrótica
dc.subjectEsclerose hepatoportal
dc.subjectVenopatia portal obliterante
dc.subjectFígado.
dc.subjectHepatotoxicidade Herbalife
dc.subjectNon-cirrhotic portal fibrosis
dc.subjectHepatoportal sclerosis
dc.subjectObliterative portal venopathy
dc.subjectLiver
dc.subjectHerbalife hepatotoxicity
dc.title Hepatoportal sclerosis related to the use of herbals and nutritional supplements. Causality or coincidence?
dc.typeArticle


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