Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy

Análisis Morfológico de la Necrosis Caseosa y su Correlación con Células CD68+ y CD8+ en Biopsias de Pleuritis Tuberculosa

dc.creatorSantana, Alessandra
dc.creatorLoureiro, Camila
dc.creatorBarbosa Junior, Aryon de Almeida
dc.creatorArruda, Sérgio Marcos
dc.date2016-03-03T17:01:17Z
dc.date2016-03-03T17:01:17Z
dc.date2009
dc.date.accessioned2023-09-26T22:17:26Z
dc.date.available2023-09-26T22:17:26Z
dc.identifierSANTANA, A. et al. Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy. International Journal of Morphology, v. 27, n. 1, p. 193-209, 2009.
dc.identifier0717-9367
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12966
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8877383
dc.descriptionTuberculosis is the most prevalent infectious disease in the world. Granuloma formation and caseous necrosis are hallmarks of M. tuberculosis infection and they represent the protective and inflammatory reactions in the infected tissues. The molecular mechanisms that mediate granuloma necrosis are still not well understood. Objectives: To immunolocalize and correlate the amounts of CD68+ macrophages and CD8+ lymphocytes to caseous necrosis extension in granulomas of tuberculous pleurisy. Methods: The study is a retrospective analysis of 30 pleural biopsies with histopathological diagnosis of chronic granulomatous pleurisy with caseous necrosis. These biopsies were classified according to necrosis intensity as minimal (N1), moderate (N2) and intense (N3). The number of granulomas was also observed and categorized as G1 (1 to 4 granulomas per section), G2 (5 to 8 granulomas per section), and G3 (more than 8 granulomas per section). Results: The means of CD68+ cells counts per mm2 in N1, N2 and N3 categories of necrosis were 1,287 ± 254, 1086 ± 181 and 930 ± 115 respectively. The means for CD8+ cells were 483.7 ± 396, 366.3 ± 43 and 558 ± 53 cells per mm2 in N1, N2 and N3 respectively. Conclusions: There were no significant statistical correlations between necrosis extension and cell counts. In analyzed biopsies, the number of CD68+ cells was significantly higher than the number of CD8+ cells.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Anatomia
dc.rightsopen access
dc.subjectTuberculous pleurisy
dc.subjectCD68+ macrophages
dc.subjectT CD8+ cells
dc.subjectCaseous necrosis
dc.titleMorphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
dc.titleAnálisis Morfológico de la Necrosis Caseosa y su Correlación con Células CD68+ y CD8+ en Biopsias de Pleuritis Tuberculosa
dc.typeArticle


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