Adipogenesis, osteogenesis, and chondrogenesis of human mesenchymal stem/stromal cells: a comparative transcriptome approach

dc.creatorRobert, Anny Waloski
dc.creatorMarcon, Bruna Hilzendeger
dc.creatorDallagiovanna, Bruno
dc.date2020-08-12T21:39:59Z
dc.date2020-08-12T21:39:59Z
dc.date2020
dc.date.accessioned2023-09-26T22:16:10Z
dc.date.available2023-09-26T22:16:10Z
dc.identifierROBERT, Anny Waloski et al. Adipogenesis, osteogenesis, and chondrogenesis of human mesenchymal stem/stromal cells: a comparative transcriptome approach. Front. Cell Dev. Biol., v. 8, n. 561, p. 1-27, 2020.
dc.identifier2296-634X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42738
dc.identifier10.3389/fcell.2020.00561
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8877090
dc.descriptionAdipogenesis, osteogenesis and chondrogenesis of human mesenchymal stem/stromal cells (MSC) are complex and highly regulated processes. Over the years, several studies have focused on understanding the mechanisms involved in the MSC commitment to the osteogenic, adipogenic and/or chondrogenic phenotypes. High-throughput methodologies have been used to investigate the gene expression profile during differentiation. Association of data analysis of mRNAs, microRNAs, circular RNAs and long non-coding RNAs, obtained at different time points over these processes, are important to depict the complexity of differentiation. This review will discuss the results that were highlighted in transcriptome analyses of MSC undergoing adipogenic, osteogenic and chondrogenic differentiation. The focus is to shed light on key molecules, main signaling pathways and biological processes related to different time points of adipogenesis, osteogenesis and chondrogenesis.
dc.formatapplication/pdf
dc.languagepor
dc.publisher2296-634X
dc.rightsopen access
dc.subjectTranscriptome Profiling
dc.subjectGene Expression Profiling
dc.subjectAdipogenesis
dc.subjectOsteogenesis
dc.subjectChondrogenesis
dc.subjectMesenchymal Stem Cells
dc.subjectCell Differentiation
dc.subjectPerfilación de la Expresión Génica
dc.subjectAdipogénesis
dc.subjectOsteogénesis
dc.subjectCondrogénesis
dc.subjectCélulas Madre Mesenquimatosas
dc.subjectDiferenciación Celular
dc.subjectAdipogenèse
dc.subjectOstéogenèse
dc.subjectChondrogenèse
dc.subjectCellules souches mésenchymateuses
dc.subjectDifférenciation cellulaire
dc.subjectPerfilação da Expressão Gênica
dc.subjectAdipogenia
dc.subjectOsteogênese
dc.subjectCondrogênese
dc.subjectCélulas-Tronco Mesenquimais
dc.subjectDiferenciação Celular
dc.titleAdipogenesis, osteogenesis, and chondrogenesis of human mesenchymal stem/stromal cells: a comparative transcriptome approach
dc.typeArticle


Este ítem pertenece a la siguiente institución