| dc.creator | Benzaken, Adele Schwartz | |
| dc.creator | Sabidó, Meritxell | |
| dc.creator | Pedroza, Valderiza | |
| dc.creator | Vasquez, Felicien | |
| dc.creator | Araújo, Adauto José Goncalves de | |
| dc.creator | Peeling, Rosanna W | |
| dc.creator | Maynaud, Phillippe | |
| dc.date | 2019-08-26T13:12:58Z | |
| dc.date | 2019-08-26T13:12:58Z | |
| dc.date | 2008 | |
| dc.date.accessioned | 2023-09-26T22:15:38Z | |
| dc.date.available | 2023-09-26T22:15:38Z | |
| dc.identifier | BENZAKEN, Adele Schwartz et al. Field evaluation of the performance and testing costs of a rapid point-of-care test for syphilis in a red-light district of Manaus, Brazil. Sexually Transmitted Infections, v. 84, n. 4, p. 1-6, 2008. | |
| dc.identifier | 1368-4973 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/35060 | |
| dc.identifier | 10.1136/sti.2008.030411 | |
| dc.identifier | 1472-3263 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8876968 | |
| dc.description | OBJECTIVES: To assess the performance, usefulness and cost of a rapid treponemal antibody assay (VisiTect Syphilis) to detect syphilis in high risk populations. METHODS: People who attended STI clinics in Manaus, Brazil, were screened for syphilis using the fluorescent treponemal antibody absorption (FTA-Abs) test and a non-treponemal test (Venereal Diseases Research Laboratory (VDRL)), and for HIV. Finger prick blood samples were tested with VisiTect Syphilis. The rapid test was evaluated against the reference FTA-Abs and for its usefulness in detecting active syphilis (FTA-Abs and VDRL positive). Operational performance was assessed through providers' and patients' interviews. An economic evaluation was conducted from the provider's perspective. RESULTS: 510 patients (60% men) were enrolled, of whom 13 (2.5%) were HIV-1 seropositive. Syphilis prevalence (FTA-Abs) was 18% and active syphilis prevalence was 7.5%. 11% (57/506) of samples were positive by VisiTect. The sensitivity, specificity, positive and negative predictive values of VisiTect Syphilis were 57% (95% CI 45.8 to 66.7), 99% (95% CI 97.0 to 99.6), 91% (95% CI 80.0 to 96.7) and 91% (95% CI 88.0 to 93.5), respectively. VisiTect Syphilis identified 79% (30/38) of active syphilis cases. The cost per case of syphilis was $16.8 for VDRL, $33.2 for low cost and $56.3 for high cost VisiTect Syphilis; the cost per case of active syphilis was $21.3, $57.5 and $97.6, respectively. Patients identified finger prick pain and preference for venous blood collection as minor barriers to test use. CONCLUSION: VisiTect Syphilis had low sensitivity in field use and was less cost effective than conventional VDRL. However, rapid and correct identification of a high proportion of active syphilis cases combined with operational characteristics suggest a role in high risk populations. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | British Association of Sexual Health and HIV | |
| dc.rights | open access | |
| dc.subject | Syphilis | |
| dc.title | Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil | |
| dc.type | Article | |
