Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency

dc.creatorAntunes, Sérgio Luiz Gomes
dc.creatorChimelli, Leila
dc.creatorJardim, Márcia Rodrigues
dc.creatorVital, Robson Teixeira
dc.creatorNery, José Augusto da Costa
dc.creatorCorte-Real, Suzana
dc.creatorHacker, Mariana Andréa Vilas Boas
dc.creatorSarno, Euzenir Nunes
dc.date2016-08-30T15:54:39Z
dc.date2016-08-30T15:54:39Z
dc.date2012
dc.date.accessioned2023-09-26T22:15:12Z
dc.date.available2023-09-26T22:15:12Z
dc.identifierANTUNES, Sérgio Luiz Gomes; et al. Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. Mem Inst Oswaldo Cruz, v.107, n.2, p. 246-253, Mar. 2012.
dc.identifier1678-8060
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/15540
dc.identifier10.1590/S0074-02762012000200015
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8876871
dc.descriptionNerve biopsy examination is an important auxiliary procedure for diagnosing pure neural leprosy (PNL). When acid-fast bacilli (AFB) are not detected in the nerve sample, the value of other nonspecific histological alterations should be considered along with pertinent clinical, electroneuromyographical and laboratory data (the detection of Mycobacterium leprae DNA with polymerase chain reaction and the detection of serum anti-phenolic glycolipid 1 antibodies) to support a possible or probable PNL diagnosis. Three hundred forty nerve samples [144 from PNL patients and 196 from patients with non-leprosy peripheral neuropathies (NLN)] were examined. Both AFB-negative and AFB-positive PNL samples had more frequent histopathological alterations (epithelioid granulomas, mononuclear infiltrates, fibrosis, perineurial and subperineurial oedema and decreased numbers of myelinated fibres) than the NLN group. Multivariate analysis revealed that independently, mononuclear infiltrate and perineurial fibrosis were more common in the PNL group and were able to correctly classify AFB-negative PNL samples. These results indicate that even in the absence of AFB, these histopathological nerve alterations may justify a PNL diagnosis when observed in conjunction with pertinent clinical, epidemiological and laboratory data.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjectHanseníase
dc.subjectDiagnóstico
dc.subjectForma neural pura
dc.subjectLeprosy
dc.subjectpure neural form
dc.subjectDiagnosis
dc.titleHistopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency
dc.typeArticle


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