Search for Antifungal and Anticancer Compounds from Native Plant Species of Cerrado and Atlantic Forest

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBolzani, Vanderlan da Silva
dc.creatorYoung, Maria Claudia M.
dc.creatorFurlan, Maysa
dc.creatorCavalheiro, Alberto José
dc.creatorAraújo, Angela Regina
dc.creatorSilva, Dulce Helena Siqueira
dc.creatorLopes, Márcia Nasser
dc.date2014-05-27T11:19:51Z
dc.date2016-10-25T18:16:09Z
dc.date2014-05-27T11:19:51Z
dc.date2016-10-25T18:16:09Z
dc.date1999-12-01
dc.date.accessioned2017-04-06T00:56:00Z
dc.date.available2017-04-06T00:56:00Z
dc.identifierAnais da Academia Brasileira de Ciencias, v. 71, n. 2, p. 180-186, 1999.
dc.identifier0001-3765
dc.identifierhttp://hdl.handle.net/11449/66030
dc.identifierhttp://acervodigital.unesp.br/handle/11449/66030
dc.identifier2-s2.0-0347183068
dc.identifier2-s2.0-0032612902
dc.identifier0000-0001-7616-9652
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887668
dc.descriptionBioactivity-guided fractionation of several bioactive extracts obtained from Cerrado and Atlantic Forest plant species led to the isolation of potent DNA-damaging piperidine 1-5 and guanidine alkaloids 6-9 from Cassia leptophylla and Pterogyne nitens respectively, two common Leguminosae from Atlantic Forest. By means of biotechnological approach on Maytenus aquifolium, a species from Cerrado, moderate DNA-damaging sesquiterpene pyridine alkaloid 10-11 was isolated. Bioassay-guided fractionation on Casearia sylvestris, a medicinal plant species found in Cerrado and Atlantic Forest, led to the isolation of clerodane diterpenes 12-13 which showed effect on DNA. In addition, we have reported several interesting potent antifungal iridoids: 1β-hydroxy-dihydrocornin (14), 1α-hydroxy-dihydrocornin (15), α-gardiol (16), β-gardiol (17), plumericin (18), isoplumericin (19), 11-O-trans-caffeoylteucrein (20); ester derivative: 2-methyl-4-hydroxy-butyl-caffeoate (21), amide N-[7-(3'.4'-methylenedioxyphenyl)-2Z, 4Z-heptadienoyl] pyrrolidine (22) and triterpene viburgenin (23).
dc.languageeng
dc.relationAnais da Academia Brasileira de Ciências
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntifungal compounds
dc.subjectAtlantic Forest
dc.subjectCerrado
dc.subjectDNA-damaging compounds
dc.titleSearch for Antifungal and Anticancer Compounds from Native Plant Species of Cerrado and Atlantic Forest
dc.typeOtro


Este ítem pertenece a la siguiente institución