Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection

dc.creatorFreitas, Isabel Ferreira LaRocque de
dc.creatorRocha, Juliana Dutra B.
dc.creatorNunes, Marise Pinheiro
dc.creatorOliveira, Priscila Angelica V.
dc.creatorNascimento, Danielle de Oliveira
dc.creatorLima, Leonardo Freire de
dc.creatorTakiya, Christina Maeda
dc.creatorMorrot, Alexandre
dc.creatorRicardo, Debora Decote
dc.creatorPreviato, Jose Osvaldo
dc.creatorPreviato, Lucia Mendonça
dc.creatorLima, Celio Geraldo Freire de
dc.date2019-01-22T15:42:06Z
dc.date2019-01-22T15:42:06Z
dc.date2018
dc.date.accessioned2023-09-26T22:14:23Z
dc.date.available2023-09-26T22:14:23Z
dc.identifierFREITAS, Isabel Fereira LaRocque de; et al. Involvement of the capsular GalXMinduced IL-17 cytokine in the control of Cryptococcus neoformans infection. Scientific Reports, v.8, 16378, 16p, Nov. 2018.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31228
dc.identifier10.1038/s41598-018-34649-4
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8876684
dc.descriptionCryptococcus neoformans is an opportunistic fungus that can cause lethal brain infections in immunosuppressed individuals. Infection usually occurs via the inhalation of a spore or desiccated yeast which can then disseminate from the lung to the brain and other tissues. Dissemination and disease is largely influence by the production of copious amounts of cryptococcal polysaccharides, both which are secreted to the extracellular environment or assembled into a thick capsule surrounding the cell body. There are two important polysaccharides: glucuronoxylomannan (GXM) and galactoxylomannan, also called as glucuronoxylomanogalactan (GXMGal or GalXM). Although GXM is more abundant, GalXM has a more potent modulatory effect. In the present study, we show that GalXM is a potent activator of murine dendritic cells, and when co-cultured with T cells, induces a Th17 cytokine response. We also demonstrated that treating mice with GalXM prior to infection with C. neoformans protects from infection, and this phenomenon is dependent on IL-6 and IL-17. These findings help us understand the immune biology of capsular polysaccharides in fungal pathogenesis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Research
dc.rightsopen access
dc.subjectCryptococcus neoformans
dc.subjectcitocina IL-17 capsulada
dc.subjectInfecção
dc.subjectGalXMinduced
dc.subjectControle
dc.subjectCryptococcus neoformans
dc.subjectInfection
dc.subjectIL-17 cytokine
dc.subjectControle
dc.subjectcapsular GalXMinduced
dc.titleInvolvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
dc.typeArticle


Este ítem pertenece a la siguiente institución