Effect of electrolytic lesion of the median raphe nucleus on behavioral and physiological measures of stress.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAndrade, T. G.
dc.creatorSilva, A. M.
dc.creatorSilva, C. L.
dc.creatorGraeff, F. G.
dc.date2014-05-27T11:19:51Z
dc.date2016-10-25T18:16:08Z
dc.date2014-05-27T11:19:51Z
dc.date2016-10-25T18:16:08Z
dc.date1999-12-01
dc.date.accessioned2017-04-06T00:55:54Z
dc.date.available2017-04-06T00:55:54Z
dc.identifierActa Physiologica Pharmacologica et Therapeutica Latinoamericana, v. 49, n. 4, p. 279-289, 1999.
dc.identifier0327-6309
dc.identifierhttp://hdl.handle.net/11449/66021
dc.identifierhttp://acervodigital.unesp.br/handle/11449/66021
dc.identifier2-s2.0-0033287717
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887659
dc.descriptionThe effect of electrolytic lesion of the median raphe nucleus was measured on behavioral and physiological parameters related to stress 24 h after the lesion. In of the elevated plus-maze the lesion decreased the percentage of open arm entries and tended to shorten the time spent on the open arms indicating an increase in anxiety. In contrast, the lesion markedly increased the time spent in the bright (aversive) compartment of the light-dark box and decrease in attempts to cross from the dark toward the bright compartment, an anxiolyic effect. With the exception of plasma prolactin level, which was lowered by the lesion, the physiological measures used in the present study indicate that the lesioned animals are under stress. Thus, death rate and weight loss after the surgery were higher in lesioned than in control animals. In addition, lesioned animals showed higher plasma corticosterone levels, a high incidence of gastric ulcers in the fundus and a depressed immune response to the mitogen concavaline A. These results highlight the importance of the median raphe nucleus in the regulation of stress and anxiety. They also show that behavioral and physiological measures of stress may be dissociated.
dc.languageeng
dc.relationActa Physiologica Pharmacologica et Therapeutica Latinoamericana
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectconcanavalin A
dc.subjectcorticosteroid
dc.subjectprolactin
dc.subjectanimal
dc.subjectanimal behavior
dc.subjectanxiety
dc.subjectblood
dc.subjectinjury
dc.subjectmale
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectraphe nucleus
dc.subjectrat
dc.subjectstomach ulcer
dc.subjectstress
dc.subjectweight reduction
dc.subjectWistar rat
dc.subjectAdrenal Cortex Hormones
dc.subjectAnimals
dc.subjectAnxiety
dc.subjectBehavior, Animal
dc.subjectConcanavalin A
dc.subjectMale
dc.subjectProlactin
dc.subjectRaphe Nuclei
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStomach Ulcer
dc.subjectStress
dc.subjectWeight Loss
dc.titleEffect of electrolytic lesion of the median raphe nucleus on behavioral and physiological measures of stress.
dc.typeOtro


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