Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates

dc.creatorMiranda, Rafaella Moraes de
dc.creatorFernandes, Rosilainy Surubi
dc.creatorFernandes, André Tavares da Silva
dc.creatorBrito, Anielly Ferreira de
dc.creatorMoreira, Silvia Bahadian
dc.creatorPereira, Renata Carvalho
dc.creatorMendes, Ygara da Silva
dc.creatorLima, Sheila Maria Barbosa de
dc.creatorPissinatti, Alcides
dc.creatorFreire, Marcos da Silva
dc.creatorAlencar, Jerônimo Augusto Fonseca
dc.creatorOliveira, Ricardo Lourenco de
dc.date2022-10-23T18:33:30Z
dc.date2022-10-23T18:33:30Z
dc.date2022
dc.date.accessioned2023-09-26T22:13:52Z
dc.date.available2023-09-26T22:13:52Z
dc.identifierMIRANDA, Rafaella Moraes de et al. Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates. Viruses, v. 14, n. 10, p. 1-10, 11 Oct. 2022.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55246
dc.identifier10.3390/v14102231
dc.identifier1999-4915
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8876564
dc.descriptionBeside humans, thousands of non-human primates (NHPs) died during the recent outbreak caused by the yellow fever virus (YFV) in Brazil. Vaccination of NHPs against YFV with the YF 17DD attenuated virus has emerged as a public health strategy, as it would reduce sylvatic transmission while also preserving endangered susceptible species. The hypothesis of establishing an uncontrolled transmission of this attenuated virus in nature was raised. We assessed vector competence of four sylvatic mosquito species, Haemagogus leucocelaenus, Haemagogus janthinomys/capricornii, Sabethes albiprivus, and Sabethes identicus, as well as the urban vector Aedes aegypti for YF 17DD attenuated vaccine virus when fed directly on eleven viremic lion tamarins or artificially challenged with the same virus. No infection was detected in 689 mosquitoes engorged on viremic lion tamarins whose viremia ranged from 1.05 × 10³ to 6.61 × 10³ FFU/mL, nor in those artificially taking ≤ 1 × 10³ PFU/mL. Low viremia presented by YF 17DD-vaccinated New World NHPs combined with the low capacity and null dissemination ability in sylvatic and domestic mosquitoes of this attenuated virus suggest no risk of its transmission in nature. Thus, vaccination of captive and free-living NHPs against YFV is a safe public health strategy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectPrimatas não humanos
dc.subjectYF 17DD
dc.subjectCompetência vetorial
dc.subjectNon-human primates
dc.subjectYF 17DD
dc.subjectVector competence
dc.titleNeotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates
dc.typeArticle


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