Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia

dc.creatorBroto, G.E.
dc.creatorSilva, P.R.B.
dc.creatorTrigo, F.C.
dc.creatorVictorino, V.J.
dc.creatorBonifácio, K.L.
dc.creatorPavanelli, W.R.
dc.creatorTomiotto-Pellissier, Fernanda
dc.creatorGarbim, M.R.
dc.creatorOliveira, S.T.
dc.creatorJumes, J.J.
dc.creatorPanis, C.
dc.creatorBarbosa, D. S.
dc.date2022-05-27T13:07:17Z
dc.date2022-05-27T13:07:17Z
dc.date2021
dc.date.accessioned2023-09-26T22:13:33Z
dc.date.available2023-09-26T22:13:33Z
dc.identifierBROTO, G.E. et al. Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia. Current Research in Immunology, n. 2, p. 163–168, 2021.
dc.identifier2590-2555
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/52952
dc.identifier10.1016/j.crimmu.2021.09.002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8876490
dc.descriptionB-cell acute lymphocytic leukemia (B-ALL) is the main neoplasia affecting children worldwide, in which cytotoxic chemotherapy remains the main treatment modality. In this study, we analyzed the profile of inflammatory markers concerning oxidative stress and cytokines in 17 B-ALL patients. Peripheral blood (PB) and bone marrow (BM) samples were collected and evaluated for the pro-oxidative status (nitric oxide products-NOx and hydroperoxides), antioxidants (sulfhydryl groups-SH and total radical-trapping antioxidant parameter-TRAP), and cytokines (TNF-α, IFN-γ), at diagnosis (D0) to and the end of the induction phase (D28). At D28, hydroperoxides were higher in PB, concomitant to TNF-α levels. INF-γ was increased in the BM at D28. Hydroperoxides were higher in patients presenting malignant cells in BM and/or PB after treatment, a condition named minimal residual disease (MRD) when compared to those without MRD at D28. These findings suggest that oxidative stress and cytokines vary across the B-ALL induction phase, and lipid peroxidation is a potential marker associated with MRD status.
dc.formatapplication/pdf
dc.languagepor
dc.publisherElsevier
dc.rightsopen access
dc.subjectB-cell acute lymphocytic leukemia
dc.subjectLeukemia, Biphenotypic, Acute
dc.subjectCytokines
dc.subjectOxidative Stress
dc.subjectPrognosis
dc.subjectMinimal residual disease
dc.subjectLipid Peroxides
dc.subjectLeucemia Bifenotípica Aguda
dc.subjectEstrés Oxidativo
dc.subjectPronóstico
dc.subjectPeróxidos Lipídicos
dc.subjectLeucémie aigüe biphénotypique
dc.subjectStress oxydatif
dc.subjectPronostic
dc.subjectMaladie résiduelle
dc.subjectPeroxydes lipidiques
dc.subjectLeucemia Aguda Bifenotípica
dc.subjectCitocinas
dc.subjectEstresse Oxidativo
dc.subjectPrognóstico
dc.subjectNeoplasia Residual
dc.subjectPeróxidos Lipídicos
dc.titleImpact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia
dc.typeArticle


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