Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure

dc.creatorBrelaz-de-Castro, Maria Carolina Accioly
dc.creatorAlmeida, Amanda Ferreira de
dc.creatorOliveira, Andresa Pereira de
dc.creatorAssis-Souza, Marina de
dc.creatorRocha, Lucas Ferreira da
dc.creatorPereira, Valéria Rêgo Alves
dc.date2018-04-04T14:07:13Z
dc.date2018-04-04T14:07:13Z
dc.date2012
dc.date.accessioned2023-09-26T22:13:02Z
dc.date.available2023-09-26T22:13:02Z
dc.identifierBRELAZ-DE-CASTRO, M. C. A. et al. Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure. Cellular Immunology, v. 279, n. 2, p. 180–186, out. 2012.
dc.identifier1090-2163
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25610
dc.identifier10.1016/j.cellimm.2012.11.006
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8876382
dc.descriptionEste trabalho foi apoiado pelo Conselho Nacional de Pesquisa (CNPq) [ 472880 / 2009-8 ] e pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) [ 23038 003155 / 2011-37 ].
dc.descriptionAmerican cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from patients before and after treatment, patients that spontaneously healed and controls, also evaluating their production of IL-10, IL-4, TNF-α and IFN-γ, after stimulation with soluble/insoluble antigenic fractions of Leishmania (Viannia) braziliensis. We observed the production of suppressive cytokines in the early phase of leishmaniasis with significant presence CD4⁺ T cells, suggesting their connection with disease progression. After healing, the immune pattern observed was a type 1 response, what seems to be associated with cure and/or protection in the ACL. The results also showed that both fractions induced a specific immune response, contributing to the search for relevant antigens in this disease.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectLeishmaniose cutânea americana
dc.subjectResposta imune
dc.subjectLinfócito T
dc.subjectAntígeno
dc.subjectCitometria de fluxo
dc.subjectCitocinas
dc.subjectAmerican cutaneous leishmaniasis
dc.subjectImmune response
dc.subjectT lymphocyte
dc.subjectAntigen
dc.subjectFlow cytometry
dc.subjectCytokines
dc.subjectAntígenos, Protozoários / imunologia
dc.subjectAgentes Antiprotozoários / uso terapêutico
dc.subjectLinfócitos T CD4-Positivos / imunologia
dc.subjectLinfócitos T CD8-Positivos / imunologia
dc.subjectLinfócitos T CD8-Positivos / parasitologia
dc.subjectCélulas Cultivadas
dc.subjectHumanos
dc.subjectInterferon gama / biossíntese
dc.subjectInterleucina-10 / biossíntese
dc.subjectInterleucina-4 / biossíntese
dc.subjectLeishmania braziliensis / imunologia
dc.subjectLeishmaniose cutânea / quimioterapia
dc.subjectLeishmaniose cutânea / imunologia
dc.subjectMeglumina / uso terapêutico
dc.subjectCompostos Organometálicos / uso terapêutico
dc.subjectFator de Necrose Tumoral alfa / biossíntese
dc.titleCellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure
dc.typeArticle


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