A Coxiella mutualist symbiont is essential to the development of Rhipicephalus microplus

dc.creatorGuizzo, Melina Garcia
dc.creatorParizi, Luís Fernando
dc.creatorNunes, Rodrigo Dutra
dc.creatorSchama, Renata
dc.creatorAlbano, Rodolpho M.
dc.creatorTirloni, Lucas
dc.creatorOldiges, Daiane Patrícia
dc.creatorVieira, Ricardo Pilz
dc.creatorOliveira, Wanderson Henrique Cruz
dc.creatorLeite, Milane de Souza
dc.creatorGonzales, Sergio A.
dc.creatorFarber, Marisa
dc.creatorMartins, Orlando
dc.creatorVaz, Itabajara da Silva
dc.creatorOliveira, Pedro L.
dc.date2018-02-08T11:01:11Z
dc.date2018-02-08T11:01:11Z
dc.date2017
dc.date.accessioned2023-09-26T22:12:53Z
dc.date.available2023-09-26T22:12:53Z
dc.identifierGUIZZO, Melina Garcia; et al. A Coxiella mutualist symbiont is essential to the development of Rhipicephalus microplus. Scientifc Reports, v.7:17554, 10p, Dec. 2017.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/24756
dc.identifier10.1038/s41598-017-17309-x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8876350
dc.descriptionThe cattle tick Rhipicephalus microplus is a hematophagous ectoparasite that causes important economic losses in livestock. Different species of ticks harbor a symbiont bacterium of the genus Coxiella. It was showed that a Coxiella endosymbiont from R. microplus (CERM) is a vertically transmitted mutualist symbiont, comprising 98% of the 16S rRNA sequences in both eggs and larvae. Sequencing of the bacterial genome revealed genes for biosynthetic pathways for several vitamins and key metabolic cofactors that may provide a nutritional complement to the tick host. The CERM was abundant in ovary and Malpighian tubule of fully engorged female. Tetracycline treatment of either the tick or the vertebrate host reduced levels of bacteria in progeny in 74% for eggs and 90% for larvae without major impact neither on the reproductive fitness of the adult female or on embryo development. However, CERM proved to be essential for the tick to reach the adult life stage, as under antibiotic treatment no tick was able to progress beyond the metanymph stage. Data presented here suggest that interference in the symbiotic CERM-R. microplus relationship may be useful to the development of alternative control methods, highlighting the interdependence between ticks and their endosymbionts.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Publishing Group
dc.rightsopen access
dc.subjectCoxiella
dc.subjectRhipicephalus microplus
dc.subjectRhipicephalus microplus
dc.subjectCoxiella
dc.subjectmutualist symbiont
dc.titleA Coxiella mutualist symbiont is essential to the development of Rhipicephalus microplus
dc.typeArticle


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