Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil

dc.creatorKauffman, Carla
dc.creatorGiacomin, Ana Caroline
dc.creatorArossi, Kelen
dc.creatorPacheco, Leandra Andressa
dc.creatorHoehne, Lucélia
dc.creatorFreitas, Elisete Maria de
dc.creatorMachado, Gérzia Maria de Carvalho
dc.creatorCavalheiro, Marilene Marcuzzo do Canto
dc.creatorGnoatto, Simone Cristina Baggio
dc.creatorEthur, Eduardo Miranda
dc.date2019-11-26T11:22:40Z
dc.date2019-11-26T11:22:40Z
dc.date2019
dc.date.accessioned2023-09-26T22:12:01Z
dc.date.available2023-09-26T22:12:01Z
dc.identifierKAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 55, p. 1-8, 2019.
dc.identifier2175-9790
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/37371
dc.identifier10.1590/s2175-97902019000217584
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8876146
dc.descriptionIn South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC‑MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for cytotoxicity against murine peritoneal macrophages. The MPEO comprised 66 components and was rich in oxygenated sesquiterpenes (82.66%) containing spathulenol (21.12%) as its major constituent. The MPEO was effective against L. amazonensis with IC50 value of 14.16 ± 7.40 µg/mL, while against L. infantum the IC50 value was higher with 101.50 ± 5.78 µg/mL. The MPEO showed significant activity against L. amazonensis, and presented a selectivity index (SI) of 6.60. The results suggest that the essential oil from leaves of M. plinioides is a promising source for new antileishmanial agents against L. amazonensis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidade de São Paulo, Faculdade de Ciências Farmacêuticas
dc.rightsopen access
dc.subjectLeishmania infantum
dc.subjectMyrciaria plinioides
dc.subjectLeishmania amazonensis
dc.subjectAtividade Antileishmanial
dc.subjectLeishmania infantum
dc.subjectMyrciaria plinioides
dc.subjectLeishmania amazonensis
dc.subjectAntileishmanial activity
dc.titleAntileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
dc.typeArticle


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