Mecanismos de absorção de aminoácidos e oligopeptídios. Controle e implicações na dietoterapia humana

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFrenhani, Patrícia Baston
dc.creatorBurini, Roberto Carlos
dc.date2014-05-27T11:19:49Z
dc.date2016-10-25T18:16:02Z
dc.date2014-05-27T11:19:49Z
dc.date2016-10-25T18:16:02Z
dc.date1999-12-01
dc.date.accessioned2017-04-06T00:55:30Z
dc.date.available2017-04-06T00:55:30Z
dc.identifierArquivos de Gastroenterologia, v. 36, n. 4, p. 227-237, 1999.
dc.identifier0004-2803
dc.identifierhttp://hdl.handle.net/11449/65967
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65967
dc.identifier10.1590/S0004-28031999000400011
dc.identifierS0004-28031999000400011
dc.identifier2-s2.0-8744275451.pdf
dc.identifier2-s2.0-8744275451
dc.identifierhttp://dx.doi.org/10.1590/S0004-28031999000400011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887611
dc.descriptionThe mechanisms involved in the absorption of amino acids and oligopeptides are reviewed regarding their implications in human feedings. Brush border and basolateral membranes are crossed by amino acids and di-tripeptides by passive (facilitated or simple diffusion) or active (Na + or H + co-transporters) pathways. Active Na +-dependent system occurs mainly at brush border and simple diffusion at basolateral, both membranes have the passive facilitated transport. Free-amino acids use either passive or active transport systems whereas di-tripeptides do mainly active (H + co-transporter). Brush border have distinctive transport system for amino acids and di-tripeptides. The former occurs mainly by active Na + dependency whereas the later is active H +-dependent with little affinity for tetra or higher peptides. Free amino acids are transported at different speed by saturable, competitive carriers with specificity for basic, acidic or neutral amino acids. Di and tripeptides have at least two carriers both electrogenic and H +-dependent. The basolateral membrane transport of amino acids is mostly by facilitated diffusion while for di-tripeptides it is an active anion exchange associated process. The main regulation of amino acids and di-tripeptide transport is the presence o substrate at the mucosal membrane with higher the substrate higher the absorption. Di and tripeptides are more efficiently absorbed than free amino acids which in turns are better absorbed than oligopeptides. So di-tripeptides result in better N-retention and is particularly useful in cases of lower intestinal absorption capacity. The non-absorbed peptides are digested and fermented by colonic bacteria resulting short-chain fatty acids, dicarboxylic acids, phenolic compounds and ammonia. Short-chain fatty acid provides energy for colonocytes and bacteria and the ammonia not fixed by bacteria returns to the liver for ureagenesis.
dc.languagepor
dc.relationArquivos de Gastroenterologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiet
dc.subjectIntestinal absorption
dc.subjectMetabolism
dc.subjectPeptides
dc.subjectProteins
dc.subjectamino acid
dc.subjectcarrier protein
dc.subjectoligopeptide
dc.subjectpeptide
dc.subjectbasement membrane
dc.subjecthuman
dc.subjectintestine absorption
dc.subjectmetabolism
dc.subjectphysiology
dc.subjectprotein intake
dc.subjectreview
dc.subjectAmino Acids
dc.subjectBasement Membrane
dc.subjectCarrier Proteins
dc.subjectDietary Proteins
dc.subjectHumans
dc.subjectIntestinal Absorption
dc.subjectOligopeptides
dc.titleMecanismos de absorção de aminoácidos e oligopeptídios. Controle e implicações na dietoterapia humana
dc.typeOtro


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