Penetration sites and migratory routes of Angiostrongylus costaricensis in the experimental intermediate host (Sarasinula marginata)

dc.creatorMendonça, Cristiane Lafetá Furtado de
dc.creatorCarvalho, Omar dos Santos
dc.creatorMota, Ester Maria
dc.creatorMachado, Marcelo Pelajo
dc.creatorCaputo, Luzia F. G.
dc.creatorLenzi, Henrique Leonel
dc.date2012-04-13T19:45:23Z
dc.date2012-04-13T19:45:23Z
dc.date1999
dc.date.accessioned2023-09-26T22:11:21Z
dc.date.available2023-09-26T22:11:21Z
dc.identifierMENDONCA, Cristiane L.G.F. et al. Penetration Sites and Migratory Routes of Angiostrongylus costaricensis in the Experimental Intermediate Host (Sarasinula marginata). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.94, n.4, p. 549-556, 1999.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3841
dc.identifier10.1590/S0074-02761999000400022
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8875984
dc.descriptionAcknowledgements to A.L. de Amorim, FF Cruz, ID Pedro (Department of Pathology, Instituto Oswaldo Cruz) for their technical assistance.
dc.descriptionThe intermediate hosts of Angiostrongylus costaricensis are terrestrian molluscs, mostly of the family Veronicellidae. The present work aimed at clarifying more accurately the sites of penetration and the migratory routes of A. costaricensis in the tissue slugs and at verifying the pattern of the perilarval reaction at different times of infection. Slugs were individually infected with 5,000 L1, and killed from 30 min to 30 days after infection. From 30 min up to 2 hr after infection, L1 were found within the lumen of different segments of the digestive tube having their number diminished in more advanced times after exposition until complete disappearance. After 30 min of exposition, percutaneous infection occurred, simultaneously to oral infection. Perilarval reaction was observed from 2 hr of infection around larvae in fibromuscular layer, appearing later (after 6 hr) around larvae located in the viscera. A pre-granulomatous reaction was characterized by gradative concentration of amebocytes around larvae, evolving two well-organized granulomas. In this work we confirmed the simultaneous occurrence of oral and percutaneous infections. Perilarval reaction, when very well developed, defined typical granulomatous structure, including epithelioid cell transformation. The infection also caused a systemic mobilization of amebocytes and provoked amebocyte-endothelium interactions.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectAngiostrongylus costaricensis
dc.subjectGranuloma
dc.subjectMigratory routes
dc.subjectAmebocytes
dc.subjectIntermediate host
dc.subjectSarasinula marginata
dc.subjectAngiostrongylus
dc.subjectInterações Hospedeiro-Parasita
dc.subjectMoluscos - parasitologia
dc.subjectInfecções por Strongylida
dc.titlePenetration sites and migratory routes of Angiostrongylus costaricensis in the experimental intermediate host (Sarasinula marginata)
dc.typeArticle


Este ítem pertenece a la siguiente institución