| dc.creator | Tavares, Maria Brandão | |
| dc.creator | Almeida, Maria da Conceição Chagas de | |
| dc.creator | Martins, Reyla Tarita Cruz | |
| dc.creator | Sousa, Ana Carolina Gil Pinho de | |
| dc.creator | Martinelli, Reinaldo | |
| dc.creator | dosSantos, Washington Luis Conrado | |
| dc.date | 2013-11-20T14:34:48Z | |
| dc.date | 2013-11-20T14:34:48Z | |
| dc.date | 2012 | |
| dc.date.accessioned | 2023-09-26T22:11:04Z | |
| dc.date.available | 2023-09-26T22:11:04Z | |
| dc.identifier | TAVARES, M. B. et al. Acute tubular necrosis and renal failure in patients with glomerular disease. Renal Failure, v. 34, n. 10, p. 1252–1257, 2012. | |
| dc.identifier | 0886-022X | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/7239 | |
| dc.identifier | 10.3109/0886022X.2012.723582 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8875914 | |
| dc.description | Renal failure is common in patients with glomerular disease. Although renal failure may result from the glomerular lesion
itself, it is also observed in patients with minimal glomerular alterations. Degenerative changes and necrosis of the tubular
epithelium are common findings in kidney biopsies from these patients. The aim of this work is to examine the association
between acute tubular necrosis (ATN) and renal failure in patients with glomerulopathy and to estimate the relationship
between the degree of ATN and renal failure in these patients. Data on age, sex, presence of nephrotic syndrome, and
renal failure were recorded for 149 patients, who underwent a renal biopsy for the diagnosis of glomerulopathy. The
biopsies were reviewed, and ATN, when present, was classified as one of four grades depending on its intensity. The
mean age of the patients was 21 16 years. Eighty patients (54%) were male, 43 (42%) had renal failure, 104 (72%) had
nephrotic syndrome, and 66 (45%) had minimal change disease or focal segmental glomerulosclerosis. ATN was present
in 115 (77%) patients. The frequency of renal failure was directly correlated with the intensity of ATN [odds ratio (OR) of
26.0 for patients with grade 2 lesions and OR of 45.5 for patients with grade 3 lesions]. ATN is a common finding in the
biopsies of patients with glomerulopathy. The severity of ATN is directly associated with the frequency of renal failure in
these patients. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Informa Healthcare USA, Inc | |
| dc.rights | open access | |
| dc.subject | Acute kidney injury | |
| dc.subject | Acute tubular necrosis | |
| dc.subject | Glomerular disease, | |
| dc.subject | Nephrotic syndrome | |
| dc.subject | Histological score | |
| dc.subject | Histopathology | |
| dc.title | Acute tubular necrosis and renal failure in patients with glomerular | |
| dc.type | Article | |
