Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects

dc.creatorFrozza, Rudimar L.
dc.creatorLourenco, Mychael V.
dc.creatorDe Felice, Fernanda G.
dc.date2018-08-30T17:23:36Z
dc.date2018-08-30T17:23:36Z
dc.date2018
dc.date.accessioned2023-09-26T22:10:52Z
dc.date.available2023-09-26T22:10:52Z
dc.identifierFROZZA, Rudimar L.; LOURENÇO, Mychael V.; De FELICE, Fernanda G. Challenges for Alzheimer’s Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects. Frontiers in Neuroscience, v.12, Article 37, 13p, Feb. 2018.
dc.identifier1662-4548,
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28479
dc.identifier10.3389/fnins.2018.00037
dc.identifier1662-453X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8875868
dc.descriptionAlzheimer's disease (AD), the most common form of dementia in late life, will become even more prevalent by midcentury, constituting a major global health concern with huge implications for individuals and society. Despite scientific breakthroughs during the past decades that have expanded our knowledge on the cellular and molecular bases of AD, therapies that effectively halt disease progression are still lacking, and focused efforts are needed to address this public health challenge. Because AD is classically recognized as a disease of memory, studies have mainly focused on investigating memory-associated brain defects. However, compelling evidence has indicated that additional brain regions, not classically linked to memory, are also affected in the course of disease. In this review, we outline the current understanding of key pathophysiological mechanisms in AD and their clinical manifestation. We also highlight how considering the complex nature of AD pathogenesis, and exploring repurposed drug approaches can pave the road toward the development of novel therapeutics for AD.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectDoença de Alzheimer
dc.subjectInflamação
dc.subjectTerapia
dc.subjectdefeitos de memória
dc.subjectpré-clínico
dc.subjectdesequilíbrios metabólicos
dc.subjectAlzheimer’s disease
dc.subjectInflammation
dc.subjectmetabolic derangements
dc.subjectmemory defects
dc.subjectpreclinical
dc.subjecttherapy
dc.titleChallenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
dc.typeArticle


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