Endogenous carotenoid concentrations in cancerous and non-cancerous tissues of gastric cancer patients in Korea

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPaiva, Sergio Alberto Rupp de
dc.creatorYeum, K. J.
dc.creatorLee, K. S.
dc.creatorPark, I. S.
dc.creatorLee-Kim, Y. C.
dc.creatorRussell, R. M.
dc.date2014-05-27T11:19:48Z
dc.date2016-10-25T18:15:58Z
dc.date2014-05-27T11:19:48Z
dc.date2016-10-25T18:15:58Z
dc.date1999-12-01
dc.date.accessioned2017-04-06T00:55:14Z
dc.date.available2017-04-06T00:55:14Z
dc.identifierAsia Pacific Journal of Clinical Nutrition, v. 8, n. 2, p. 160-166, 1999.
dc.identifier0964-7058
dc.identifierhttp://hdl.handle.net/11449/65928
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65928
dc.identifier10.1046/j.1440-6047.1999.00087.x
dc.identifier2-s2.0-24044515580
dc.identifierhttp://dx.doi.org/10.1046/j.1440-6047.1999.00087.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887580
dc.descriptionCarotenoid concentrations were measured in serum and in both non-cancerous and cancerous gastric mucosal tissues of Korean patients with gastric cancer (n = 18). Carotenoids in serum and gastric tissue were extracted with chloroform/methanol (2:1), and measured using reverse-phase high-performance liquid chromatography with a C30 column. Cryptoxanthin and β-carotene were the major carotenoids in the Korean blood and they had a median ratio of non-cancerous tissue/serum levels which was less than 1.0. No significant differences of Cryptoxanthin and β-carotene levels were found between non-cancerous and cancerous tissues. After incubation of β-carotene with gastric tissue, significantly higher levels of β-carotene breakdown products were produced in the homogenates of cancerous tissue when compared with non-cancerous tissue. Lutein, zeaxanthin and α-carotene were the minor carotenoid constituents in the blood and their median ratio of non-cancerous tissue/serum levels was greater than 1.0. Cancerous tissue had significantly lower levels of lutein, zeaxanthin and α-carotene than did non-cancerous tissue. It appears that the increased breakdown of β-carotene and cryptoxanthin in cancerous tissue can be compensated for by an increased uptake of circulating carotenoids by cancerous tissue, whereas lutein, zeaxanthin and α-carotene levels in cancerous tissue are not able to be maintained.
dc.languageeng
dc.relationAsia Pacific Journal of Clinical Nutrition
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectβ-carotene
dc.subjectCarotenoids
dc.subjectCryptoxanthin
dc.subjectGastric cancer
dc.subjectKorea
dc.subjectLycopene
dc.subjectMucosa
dc.subjectSerum
dc.titleEndogenous carotenoid concentrations in cancerous and non-cancerous tissues of gastric cancer patients in Korea
dc.typeOtro


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