Anterior-Segment Ocular Findings and Microphthalmia in Congenital Zika Syndrome

dc.creatorFreitas, Bruno de Paula
dc.creatorZin, Andrea A.
dc.creatorKo, Albert Icksang
dc.creatorMaia, Maurício
dc.creatorVentura, Camila V
dc.creatorBelfort, Rubens
dc.date2020-06-15T19:38:20Z
dc.date2020-06-15T19:38:20Z
dc.date2017
dc.date.accessioned2023-09-26T22:10:29Z
dc.date.available2023-09-26T22:10:29Z
dc.identifierFreitas B. de Paula, Zin A, Ko A, Maia M, Ventura CV, Belfort R Jr. Anterior-Segment Ocular Findings and Microphthalmia in Congenital Zika Syndrome. Ophthalmology. 2017;124(12):1876-1878. doi:10.1016/j.ophtha.2017.06.009
dc.identifier0161-6420
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/41659
dc.identifier10.1016/j.ophtha.2017.06.009
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8875775
dc.descriptionAn additional fee is required to make the article Open Access.
dc.descriptionO vírus Zika (ZIKV) é um vírus neurotrópico que pode atacar o sistema nervoso central e causar microcefalia, comprometimento do desenvolvimento neurológico e anormalidades esqueléticas, auditivas e oculares graves por transmissão vertical.1, 2, 3, 4 A ampla variedade de anomalias congênitas associado à transmissão vertical do ZIKV é referido como "síndrome congênita do zika" (CZS). A maioria dos estudos que abordaram os achados oculares em pacientes com CZS identificou alterações do segmento posterior, como atrofia coriorretiniana, manchas de pigmento e anormalidades do nervo óptico.1, 2, 3, 4 No entanto, no início de fevereiro de 2016, nosso grupo relatou o primeiro caso da CZS com achados do segmento anterior, incluindo subluxação da lente e coloboma de íris bilateral.1 Posteriormente, descrevemos o primeiro caso de glaucoma congênito relacionado à CZS.5. O objetivo deste estudo foi descrever uma série de casos de bebês com infecção congênita pelo ZIKV que desenvolveram malformações oculares estruturais, incluindo microftalmia, coloboma da íris e catarata.
dc.descriptionThe Zika virus (ZIKV) is a neurotropic virus that can attack the central nervous system and cause microcephaly, neurodevelopmental impairment, and severe skeletal, hearing, and ocular abnormalities by vertical transmission.1, 2, 3, 4 The wide range of congenital abnormalities associated with the vertical transmission of the ZIKV is referred to as “congenital Zika syndrome” (CZS). Most studies that have addressed the ocular findings in patients with CZS identified posterior segment alterations, such as chorioretinal atrophy, pigment mottling, and optic nerve abnormalities.1, 2, 3, 4 However, in early February 2016, our group reported the first case of CZS with anterior-segment findings including lens subluxation and bilateral iris coloboma.1 Subsequently, we described the first case of congenital glaucoma related to CZS.5. The aim of this study was to describe a case series of infants with the congenital ZIKV infection who developed structural ocular malformations, including microphthalmia, iris coloboma, and cataract.
dc.description2200-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier [Commercial Publisher]; American Academy of Ophthalmology [Associate Organisation]
dc.rightsrestricted access
dc.subjectZika Virus Infection / virology
dc.subjectZika Virus Infection / diagnosis
dc.subjectZika Virus Infection / congenital
dc.subjectZika Virus / immunology
dc.subjectZika Virus / genetics
dc.subjectReal-Time Polymerase Chain Reaction
dc.subjectPregnancy Complications, Infectious
dc.subjectPregnancy
dc.subjectMicrophthalmos / virology
dc.subjectMicrophthalmos / diagnosis
dc.subjectMale
dc.subjectIris / abnormalities
dc.subjectInfant, Newborn
dc.subjectInfant
dc.subjectHumans
dc.subjectFemale
dc.subjectEye Infections, Viral / virology
dc.subjectEye Infections, Viral / diagnosis
dc.subjectDNA, Viral / genetics
dc.subjectColoboma / virology
dc.subjectColoboma / diagnosis
dc.subjectCataract / congenital
dc.subjectAnterior Eye Segment / virology
dc.subjectAnterior Eye Segment / abnormalities
dc.titleAnterior-Segment Ocular Findings and Microphthalmia in Congenital Zika Syndrome
dc.typeArticle


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