Increased concentrations of IL-18 and uric acid in sickle cell anemia: contribution of hemolysis, endothelial activation and the inflammasome.

dc.creatorCerqueira, Bruno Antonio Veloso
dc.creatorSantos, Wendell Vilas Boas
dc.creatorZanette, Angela Maria Dias
dc.creatorReis, Mitermayer Galvão dos
dc.creatorGonçalves, Marilda de Souza
dc.date2014-07-14T13:56:39Z
dc.date2014-07-14T13:56:39Z
dc.date2011
dc.date.accessioned2023-09-26T22:09:06Z
dc.date.available2023-09-26T22:09:06Z
dc.identifierCERQUEIRA, B. A. V. et al. Increased concentrations of IL-18 and uric acid in sickle cell anemia: contribution of hemolysis, endothelial activation and the inflammasome. Cytokine, v. 56, n. 2, p. 471-476, 2011.
dc.identifier1096-0023
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7946
dc.identifier:10.1016/j.cyto.2011.08.013
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8875444
dc.descriptionSickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis, frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, resulting in painful crises, organ damage and premature death. This study evaluated associations between serum levels of IL-18, uric acid, hemolytic markers, and inflammatory molecules in SCA patients. A cross-sectional study was performed including 45 SCA patients (median age of 20.5 years) without general symptoms and who had not undergone blood transfusions. Inclusion criteria for the steady-state SCA patients were the absence of hospitalization and the absence of infections. Interleukin-18 and uric acid levels were correlated closely with markers of hemolysis, endothelial dysfunction and others cytokines levels. These findings suggest probable influences of IL-18 and uric acid in the pathophysiology of vascular occlusion in SCA. Additional studies should be performed to characterize similar prognosis markers and possible therapeutic targets.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Ltd
dc.rightsopen access
dc.subjectSickle cell anemia
dc.subjectCytokine
dc.subjectInflammation
dc.subjectAnemia Falciforme/sangue
dc.subjectEndotélio Vascular/metabolismo
dc.subjectHemólise
dc.subjectInflamassomos/metabolismo
dc.subjectInterleucina-18/sangue
dc.subjectÁcido Úrico/sangue
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectMoléculas de Adesão Celular/metabolismo
dc.subjectEstudos Transversais
dc.subjectEndotélio Vascular/patologia
dc.subjectFeminino
dc.subjectHumanos
dc.subjectMasculino
dc.titleIncreased concentrations of IL-18 and uric acid in sickle cell anemia: contribution of hemolysis, endothelial activation and the inflammasome.
dc.typeArticle


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