| dc.creator | Silva, Ygor Parladore | |
| dc.creator | Bernardi, Andressa | |
| dc.creator | Frozza, Rudimiar Luiz | |
| dc.date | 2020-06-03T15:15:50Z | |
| dc.date | 2020-06-03T15:15:50Z | |
| dc.date | 2020 | |
| dc.date.accessioned | 2023-09-26T22:08:20Z | |
| dc.date.available | 2023-09-26T22:08:20Z | |
| dc.identifier | SILVA, Ygor Parladore; BERNARDI, Andressa; FROZZA, Rudimar Luiz. The role of short-chain fatty acids from Gut Microbiota in Gut-Brain communication. Frontiers in Endocrinology, v. 11, Article 25, 14p, Jan. 2020. | |
| dc.identifier | 1664-2392 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/41503 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8875275 | |
| dc.description | A substantial body of evidence supports that the gut microbiota plays a pivotal role in
the regulation of metabolic, endocrine and immune functions. In recent years, there has
been growing recognition of the involvement of the gut microbiota in the modulation
of multiple neurochemical pathways through the highly interconnected gut-brain axis.
Although amazing scientific breakthroughs over the last few years have expanded our
knowledge on the communication between microbes and their hosts, the underpinnings
of microbiota-gut-brain crosstalk remain to be determined. Short-chain fatty acids
(SCFAs), the main metabolites produced in the colon by bacterial fermentation of dietary
fibers and resistant starch, are speculated to play a key role in neuro-immunoendocrine
regulation. However, the underlying mechanisms through which SCFAs might influence
brain physiology and behavior have not been fully elucidated. In this review, we outline the
current knowledge about the involvement of SCFAs in microbiota-gut-brain interactions.
We also highlight how the development of future treatments for central nervous system
(CNS) disorders can take advantage of the intimate and mutual interactions of the
gut microbiota with the brain by exploring the role of SCFAs in the regulation of
neuro-immunoendocrine function. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Frontiers Media | |
| dc.rights | open access | |
| dc.subject | Sistema nervoso central | |
| dc.subject | Neuroinflamação | |
| dc.subject | Micróbio intestinal | |
| dc.subject | Ácidos graxos de cadeia curta | |
| dc.subject | Central nervous system | |
| dc.subject | Neuroinflammation | |
| dc.subject | Gut-brain axis | |
| dc.subject | Gut microbiota | |
| dc.subject | Short-chain fatty acids | |
| dc.title | The role of short-chain fatty acids from gut microbiota in gut-brain communication | |
| dc.type | Article | |
