Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.

dc.creatorZanette, Angela Maria Dias
dc.creatorGonçalves, Marilda de Souza
dc.creatorSchettini, Laíse Vilasboas
dc.creatorAguiar, Lais Magalhães
dc.creatorBahia, Regina Célia Santos
dc.creatorNogueira, Luciana Araujo Vasconcelos
dc.creatorBrandão, Cláudio José de Freitas
dc.creatorAzevedo, Ana Claudia Neves de
dc.creatorAragao, Luciana Ramos de
dc.creatorArruda, Sérgio Marcos
dc.date2014-12-04T14:30:30Z
dc.date2014-12-04T14:30:30Z
dc.date2010
dc.date.accessioned2023-09-26T22:08:19Z
dc.date.available2023-09-26T22:08:19Z
dc.identifierZANETTE, A. M. D. et al. Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil. Ethnicity & Disease, v. 20, n. 2, p. 136-141, 2010.
dc.identifier1049-510X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9043
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8875271
dc.descriptionSickle cell disease (SCD) is an important public health issue in Bahia, Brazil. Erythrocyte transfusions may reduce morbidity of SCD, however, they are associated with numerous risks. Among other risk categories, alloimmunization to red cell antigens may result from transfusions. The aim of this study was to compare the clinical profile of transfused adult SCD patients with and without alloantibodies. The study included 108 patients (105 homozygous SS and three with hemoglobinopathy SC), followed in the Outpatient Unit of the Hematology and Hemotherapy Center of Bahia. A retrospective review of clinical records of adult SCD patients who received at least three red blood cell transfusions from 2004 to 2007 was performed. Transfusion units were phenotypically matched for ABH-D and C,c,E,e, and K antigens. Alloimmunization developed in 56 patients (53 SS and three SC). The most prevalent alloantibodies were anti-E, anti-K, and anti-C (39.3%, 21.4%, and 16.1%, respectively). Age, sex and positive antiglobulin test displayed statistically significant differences. Prevalence of clinical complications such as leg ulcers, stroke, and others did not show differences between groups. In conclusion, alloimmunization did not significantly modify the clinical outcomes of SCD patients from Bahia, Brazil.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInternational Society on Hypertension in Blacks
dc.rightsopen access
dc.subjectSickle Cell Disease
dc.subjectHemoglobinopathy
dc.subjectAlloimmunization
dc.subjectRed Cell Transfusion
dc.subjectAnemia Falciforme/terapia
dc.subjectTransfusão de Eritrócitos/efeitos adversos
dc.subjectIsoanticorpos
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectAnemia Falciforme/complicações
dc.subjectBrasil/epidemiologia
dc.subjectTeste de Coombs
dc.subjectEstudos Transversais
dc.subjectFeminino
dc.subjectHumanos
dc.subjectÚlcera da Perna/complicações
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectAmbulatório Hospitalar/estatística & dados numéricos
dc.subjectPrevalência
dc.subjectEstudos Retrospectivos
dc.subjectAcidente Vascular Cerebral/complicações
dc.subjectAdulto Jovem
dc.titleAlloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
dc.typeArticle


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