Long-term nitric oxide inhibition and chronotropic responses in rat isolated right atria

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRiado, Sonia R.
dc.creatorZanesco, Angelina
dc.creatorBarker, Louis Allen
dc.creatorDe Luca, Iara M.S.
dc.creatorAntunes, Edson
dc.creatorDe Nucci, Gilberto
dc.date2014-05-27T11:19:46Z
dc.date2016-10-25T18:15:51Z
dc.date2014-05-27T11:19:46Z
dc.date2016-10-25T18:15:51Z
dc.date1999-10-01
dc.date.accessioned2017-04-06T00:54:44Z
dc.date.available2017-04-06T00:54:44Z
dc.identifierHypertension, v. 34, n. 4 II, p. 802-807, 1999.
dc.identifier0194-911X
dc.identifierhttp://hdl.handle.net/11449/65847
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65847
dc.identifier10.1161/01.HYP.34.4.802
dc.identifierWOS:000083486500018
dc.identifier2-s2.0-0032759169
dc.identifierhttp://dx.doi.org/10.1161/01.HYP.34.4.802
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887519
dc.descriptionThe long-term administration of nitric oxide synthesis inhibitors induces arterial hypertension accompanied by left ventricular hypertrophy and myocardial ischemic lesions. Because the enhancement of sympathetic drive has been implicated in these phenomena, the current study was performed to determine the potency of β-adrenoceptor agonists and muscarinic agonists on the spontaneous rate of isolated right atria from rats given long-term treatment with the nitric oxide inhibitor N(ω)-nitro-L-arginine methyl ester (L-NAME). Atrial lesions induced by long-term treatment with L-NAME were also evaluated. Long-term L-NAME treatment caused a time-dependent, significant (P<0.05) increase in tail-cuff pressure compared with control animals. Our results showed that the potency of isoproterenol, norepinephrine, carbachol, and pilocarpine in isolated right atria from rats given long-term treatment with L-NAME for 7, 15, 30, and 60 days was not affected as compared with control animals. Addition of L-NAME in vitro (100 μmol/L) affected neither basal rate nor chronotropic response for isoproterenol and norepinephrine in rat heart. Stereological analysis of the right atria at 15 and 30 days revealed a significant increase on amount of fibrous tissues in L-NAME- treated groups (27±2.3% and 28±1.3% for 15 and 30 days, respectively; P<0.05) as compared with the control group (22±1.1%). Our results indicate that nitric oxide does not to interfere with β-adrenoceptor-mediated and muscarinic receptor-mediated chronotropic responses.
dc.languageeng
dc.relationHypertension
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdrenergic receptor agonists
dc.subjectBlood pressure
dc.subjectNitric oxide
dc.subjectReceptors, adrenergic, beta
dc.subjectReceptors, muscarinic
dc.subjectcarbachol
dc.subjectisoprenaline
dc.subjectn(g) nitroarginine methyl ester
dc.subjectnitric oxide
dc.subjectnoradrenalin
dc.subjectpilocarpine
dc.subjectadrenergic system
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectblood pressure measurement
dc.subjectchronotropism
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectdrug potency
dc.subjectheart right atrium
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectAnimals
dc.subjectBlood Pressure
dc.subjectEnzyme Inhibitors
dc.subjectHeart Atria
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectNG-Nitroarginine Methyl Ester
dc.subjectNitric Oxide
dc.subjectNitric Oxide Synthase
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSympathetic Nervous System
dc.subjectVentricular Function, Right
dc.titleLong-term nitric oxide inhibition and chronotropic responses in rat isolated right atria
dc.typeOtro


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