Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?

dc.creatorPiergiorge, Rafael Mina
dc.creatorMiranda, Antonio Basílio de
dc.creatorGuimarães, Ana Carolina
dc.creatorCatanho, Marcos
dc.date2018-02-15T12:03:39Z
dc.date2018-02-15T12:03:39Z
dc.date2017
dc.date.accessioned2023-09-26T22:07:56Z
dc.date.available2023-09-26T22:07:56Z
dc.identifierPIERGIORGE, Rafael Mirna; et al. Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?. Genome Biol. Evol., v. 9, n.6, p.1624–1636, July 2017.
dc.identifier1759-6653
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/24815
dc.identifier10.1093/gbe/evx119
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8875180
dc.descriptionSince enzymes catalyze almost all chemical reactions that occur in living organisms, it is crucial that genes encoding such activities are correctly identified and functionally characterized. Several studies suggest that the fraction of enzymatic activities in which multiple events of independent origin have taken place during evolution is substantial. However, this topic is still poorly explored, and a comprehensive investigation of the occurrence, distribution, and implications of these events has not been done so far. Fundamental questions, such as how analogous enzymes originate, why somany events of independent origin have apparently occurred during evolution, and what are the reasons for the coexistence in the same organism of distinct enzymatic forms catalyzing the same reaction, remain unanswered. Also, several isofunctional enzymes are still not recognized as nonhomologous, evenwith substantial evidence indicating different evolutionary histories. In this work, we begin to investigate the biological significance of the cooccurrence of nonhomologous isofunctional enzymes in human metabolism, characterizing functional analogous enzymes identified in metabolic pathways annotated in the human genome.Our hypothesis is that the coexistence of multiple enzymatic forms might not be interpreted as functional redundancy. Instead, these enzymatic forms may be implicated in distinct (and probably relevant) biological roles.
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectHomo sapiens
dc.subjectAtividade enzimática
dc.subjectEvolução convergente
dc.subjectenzymatic activity
dc.subjectconvergent evolution
dc.subjectH. sapiens
dc.titleFunctional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
dc.typeArticle


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