Trypanosoma cruzi: Desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect.

dc.creatorArantes, Jerusa Marilda
dc.creatorFrancisco, Amanda Fortes
dc.creatorVieira, Paula Melo de Abreu
dc.creatorSilva, Maisa
dc.creatorAraújo, Márcio Sobreira Silva
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorPedrosa, Maria Lúcia
dc.creatorCarneiro, Cláudia Martins
dc.creatorTafuri, Washington Luiz
dc.creatorMartins Filho, Olindo Assis
dc.creatorSantos, Silvana Maria Elói
dc.date2015-08-25T14:44:02Z
dc.date2015-08-25T14:44:02Z
dc.date2011
dc.date.accessioned2023-09-26T22:06:32Z
dc.date.available2023-09-26T22:06:32Z
dc.identifierARANTES, Jerusa Marilda et al. Trypanosoma cruzi: Desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect. Exp Parasitol, vol. 128, n. 4, p. 401-408, 2011.
dc.identifier0014-4894
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11646
dc.identifier10.1016/j.exppara.2011.05.011
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874846
dc.descriptionDesferrioxamine (DFO) is a potent iron chelator that is also known to modulate inflammation and act as an efficient antioxidant under normal conditions and under oxidative stress. Many in vitro and in vivo studies have shown the efficacy of DFO in the treatment of viral, bacterial and protozoan infections. DFO is known to reduce the intensity of Trypanosoma cruzi infections in mice even during a course of therapy that is not effective in maintaining anaemia or low iron levels. To further clarify these findings, we investigated the action of DFO on mouse T. cruzi infection outcomes and the direct impact of DFO on parasites. Infected animals treated with DFO (5 mg/animal/day) for 35 days, beginning 14 days prior to infection, presented lower parasitemia and lower cumulative mortality rate. No significant effect was observed on iron metabolism markers, erythrograms, leukograms or lymphocyte subsets. In the rapid method for testing in vivo T. cruzi susceptibility, DFO also induced lower parasitemia. In regard to its direct impact on parasites, DFO slightly inhibited the growth of amastigotes and trypomastigotes in fibroblast culture. Trypan blue staining showed no effects of DFO on parasite viability, and only minor apoptosis in trypomastigotes was observed. Nevertheless, a clear decrease in parasite mobility was detected. In conclusion, the beneficial actions of DFO on mice T. cruzi infection seem to be independent of host iron metabolism and free of significant haematological side effects. Through direct action on the parasite, DFO has more effective trypanostatic than trypanocidal properties.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAcademic Press
dc.rightsrestricted access
dc.subjectTrypanosoma cruzi
dc.subjectDesferrioxamine
dc.subjectEtiological treatment
dc.subjectExperimental infection
dc.subjectTrypanostatic effect
dc.titleTrypanosoma cruzi: Desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect.
dc.typeArticle


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