dc.creator | Calvet, Guilherme Amaral | |
dc.creator | Kara, Edna Oliveira | |
dc.creator | Giozza, Silvana Pereira | |
dc.creator | Menezes, Camila Helena Aguiar Bôtto | |
dc.creator | Gaillard, Philippe | |
dc.creator | Franca, Rafael Freitas de Oliveira | |
dc.creator | Lacerda, Marcus Vinicius Guimarães de | |
dc.creator | Castilho, Marcia da Costa | |
dc.creator | Brasil, Patrícia | |
dc.creator | Sequeira, Patrícia Carvalho de | |
dc.creator | Mello, Maeve Brito de | |
dc.creator | Bermudez, Ximena Pamela Diaz | |
dc.creator | Modjarrad, Kayvon | |
dc.creator | Meurant, Robyn | |
dc.creator | Landoulsi, Sihem | |
dc.creator | Benzaken, Adele Schwartz | |
dc.creator | Filippis, Ana Maria Bispo de | |
dc.creator | Broutet, Nathalie Jeanne Nicole | |
dc.date | 2018-08-02T12:19:44Z | |
dc.date | 2018-08-02T12:19:44Z | |
dc.date | 2018 | |
dc.date.accessioned | 2023-09-26T22:06:26Z | |
dc.date.available | 2023-09-26T22:06:26Z | |
dc.identifier | CALVET, Guilherme Amaral et al. Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil. BMC Infectious Diseases, v. 18, p. 1-17, 2018. | |
dc.identifier | 1471-2334 | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/27783 | |
dc.identifier | 10.1186/s12879-018-2965-4 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8874824 | |
dc.description | Background: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission. Methods: This observational cohort study will recruit non-pregnant participants aged 18 years and above with
confirmed ZIKV infection [positive reverse transcriptase-polymerase chain reaction (RT-PCR) test in blood and/or urine]: symptomatic men and women in ZIKV infection acute phase, and their symptomatic or asymptomatic household/sexual infected contacts. Specimens of blood, urine, semen, vaginal secretion/menstrual blood, rectal swab, oral fluids, tears, sweat, urine and breast milk (if applicable) will be collected at pre-established intervals and tested for ZIKV RNA presence by RT-PCR, other co-infection (dengue, Chikungunya, HIV, hepatitis B and C, syphilis), antibody response (including immunoglobulins M and G), plaque reduction neutralization test (if simultaneously positive for ZIKV and dengue), and ZIKV culture and RNA sequencing. Data on socio-demographic characteristics and comorbidities will be collected in parallel. Participants will be followed up for 12 months. Discussion: This prolonged longitudinal follow-up of ZIKV infected persons with regular biologic testing and data
collection will offer a unique opportunity to investigate the presence and persistence of ZIKV in various biologic compartments, their clinical and immunological correlates as well as the possibility of ZIKV reactivation/reinfection over time. This valuable information will substantially contribute to the body of knowledge on ZIKV infection and
serve as a base for the development of more effective recommendation on the prevention of ZIKV transmission. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | BioMed Central | |
dc.rights | open access | |
dc.subject | Arbovirus | |
dc.subject | Flavivírus | |
dc.subject | Zika virus | |
dc.subject | Fluidos corporais | |
dc.subject | Persistência | |
dc.subject | Doenças infecciosas emergentes | |
dc.subject | Reação em Cadeia da Polimerase em Tempo Real | |
dc.subject | Brasil | |
dc.subject | Arbovirus | |
dc.subject | Flavivirus | |
dc.subject | Zika virus | |
dc.subject | Body fluids | |
dc.subject | Persistence | |
dc.subject | Rt-Pcr | |
dc.subject | Emerging infectious diseases | |
dc.subject | Brazil | |
dc.subject | Reação em Cadeia da Polimerase em Tempo Real | |
dc.title | Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil | |
dc.type | Article | |