Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil

dc.creatorCalvet, Guilherme Amaral
dc.creatorKara, Edna Oliveira
dc.creatorGiozza, Silvana Pereira
dc.creatorMenezes, Camila Helena Aguiar Bôtto
dc.creatorGaillard, Philippe
dc.creatorFranca, Rafael Freitas de Oliveira
dc.creatorLacerda, Marcus Vinicius Guimarães de
dc.creatorCastilho, Marcia da Costa
dc.creatorBrasil, Patrícia
dc.creatorSequeira, Patrícia Carvalho de
dc.creatorMello, Maeve Brito de
dc.creatorBermudez, Ximena Pamela Diaz
dc.creatorModjarrad, Kayvon
dc.creatorMeurant, Robyn
dc.creatorLandoulsi, Sihem
dc.creatorBenzaken, Adele Schwartz
dc.creatorFilippis, Ana Maria Bispo de
dc.creatorBroutet, Nathalie Jeanne Nicole
dc.date2018-08-02T12:19:44Z
dc.date2018-08-02T12:19:44Z
dc.date2018
dc.date.accessioned2023-09-26T22:06:26Z
dc.date.available2023-09-26T22:06:26Z
dc.identifierCALVET, Guilherme Amaral et al. Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil. BMC Infectious Diseases, v. 18, p. 1-17, 2018.
dc.identifier1471-2334
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27783
dc.identifier10.1186/s12879-018-2965-4
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874824
dc.descriptionBackground: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission. Methods: This observational cohort study will recruit non-pregnant participants aged 18 years and above with confirmed ZIKV infection [positive reverse transcriptase-polymerase chain reaction (RT-PCR) test in blood and/or urine]: symptomatic men and women in ZIKV infection acute phase, and their symptomatic or asymptomatic household/sexual infected contacts. Specimens of blood, urine, semen, vaginal secretion/menstrual blood, rectal swab, oral fluids, tears, sweat, urine and breast milk (if applicable) will be collected at pre-established intervals and tested for ZIKV RNA presence by RT-PCR, other co-infection (dengue, Chikungunya, HIV, hepatitis B and C, syphilis), antibody response (including immunoglobulins M and G), plaque reduction neutralization test (if simultaneously positive for ZIKV and dengue), and ZIKV culture and RNA sequencing. Data on socio-demographic characteristics and comorbidities will be collected in parallel. Participants will be followed up for 12 months. Discussion: This prolonged longitudinal follow-up of ZIKV infected persons with regular biologic testing and data collection will offer a unique opportunity to investigate the presence and persistence of ZIKV in various biologic compartments, their clinical and immunological correlates as well as the possibility of ZIKV reactivation/reinfection over time. This valuable information will substantially contribute to the body of knowledge on ZIKV infection and serve as a base for the development of more effective recommendation on the prevention of ZIKV transmission.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectArbovirus
dc.subjectFlavivírus
dc.subjectZika virus
dc.subjectFluidos corporais
dc.subjectPersistência
dc.subjectDoenças infecciosas emergentes
dc.subjectReação em Cadeia da Polimerase em Tempo Real
dc.subjectBrasil
dc.subjectArbovirus
dc.subjectFlavivirus
dc.subjectZika virus
dc.subjectBody fluids
dc.subjectPersistence
dc.subjectRt-Pcr
dc.subjectEmerging infectious diseases
dc.subjectBrazil
dc.subjectReação em Cadeia da Polimerase em Tempo Real
dc.titleStudy on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil
dc.typeArticle


Este ítem pertenece a la siguiente institución